ESS2 and LYST

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro)

		ESS2	LYST
Description		ess-2 splicing factor homolog	lysosomal trafficking regulator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Catalytic Step 2 Spliceosome	Cytosol Microtubule Cytoskeleton Membrane
	Molecular Function	Molecular_function Protein Binding	Protein Binding Protein Kinase Binding
	Biological Process	MRNA Splicing, Via Spliceosome Nervous System Development	Phagocytosis Lysosome Organization Protein Localization Protein Transport Leukocyte Chemotaxis Melanosome Organization Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Mast Cell Secretory Granule Organization Natural Killer Cell Mediated Cytotoxicity Defense Response To Bacterium Defense Response To Protozoan Pigmentation Defense Response To Virus
Pathways
Drugs
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS			Basophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Systemic lupus erythematosus ( 26502338 19838195)
Interacting Genes		18 interacting genes: ARMC7 CCDC57 CDK5RAP3 CRP DGCR6 DHX16 EXOC8 FRA10AC1 LYST OIP5 PFDN1 QARS1 RACK1 RBM4 SMARCD1 TTC14 VIM WNK2	24 interacting genes: ATN1 CALM1 CELF4 CENPJ CNTROB CSNK2B DNAJC14 EFS ESRRA ESS2 HGS HNRNPM KPNB1 MED12 MRPL17 MRPS31 NCDN PCBP4 TNNI3 VTA1 YWHAB YWHAQ YWHAZ ZNF521
Entrez ID		8220	1130
HPRD ID		03452	06060
Ensembl ID		ENSG00000100056	ENSG00000143669
Uniprot IDs		F8WEF8 Q96DF8	Q99698
PDB IDs
Enriched GO Terms of Interacting Partners?
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