CLPP and DTX2

Data Source:
BioGRID (two hybrid)

		CLPP	DTX2
Description		caseinolytic mitochondrial matrix peptidase proteolytic subunit	deltex E3 ubiquitin ligase 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Endopeptidase Clp Complex	Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	Endopeptidase Activity ATP-dependent Peptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Identical Protein Binding ATPase Binding	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Membrane Protein Proteolysis Proteolysis Involved In Cellular Protein Catabolic Process	Notch Signaling Pathway Protein Ubiquitination
Pathways			Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus
Drugs		N-Formylmethionine
Diseases
GWAS
Interacting Genes		16 interacting genes: ABI2 C14orf119 CLPX DTX2 EFEMP1 EFEMP2 GRN KRTAP10-1 NUTF2 P4HA3 PLSCR4 PPP2CA PSMB1 RBPMS TNPO3 TRIM54	131 interacting genes: ABHD11 ABHD16A ALKBH4 ANAPC11 ANTKMT ARID5A ARMC7 ARNT2 BCL2L11 BICRAL BOLA2-SMG1P6 C10orf55 C11orf1 C19orf54 C1orf94 C20orf85 C22orf39 CCDC57 CLPP COA6 COQ8A DAZAP2 DOK3 DTX1 DTX3 ECM1 ECSIT EIF4ENIF1 EIF4G1 EYA2 FAM168A FCRL4 FHL2 FHL5 FOXI1 FTO GLYCTK GOLGA2 HDC HGS HLX HOXA1 HOXB2 HOXD12 HPCA HPCAL1 HPCAL4 HSFY1 HSFY2 IKZF3 KANK2 KLC3 KLHDC7B KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP26-1 KRTAP6-1 KRTAP7-1 KRTAP8-1 LASP1 LNX1 LRP2BP MBD3L1 MDC1 MED19 MSS51 MVP MXRA8 NCALD NCS1 NHLRC4 NIF3L1 NME4 NOTCH1 OIP5 PARP1 PAX5 PLEKHF2 PLEKHG4 PLSCR1 POGZ PPP1R32 PRR32 PRR34 PSMB4 QARS1 RBM11 RBPMS RFX6 RHOXF2 RIMBP3 RUNX1 RUSC1 SEC22A SEC23A SEC23B SEPSECS SLC22A18AS SOHLH1 SPAG8 SPG21 STX12 SUMO1 TBX15 TEKT5 TENT2 TMEM42 TRIB3 TRIM35 TRIM54 TRIP13 TRIP6 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBQLN4 USP54 VGLL3 VSNL1 ZNF34 ZNF503 ZNF620 ZNF641 ZNF764 ZNF774 ZNF85
Entrez ID		8192	113878
HPRD ID		03074	16841
Ensembl ID		ENSG00000125656	ENSG00000091073
Uniprot IDs		Q16740	Q86UW9
PDB IDs		1TG6 6BBA 6DL7 6H23	6IR0 6Y22 6Y2X 6Y3J
Enriched GO Terms of Interacting Partners?
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