CAMLG and KCNE4

Data Source:
BioGRID (two hybrid)

		CAMLG	KCNE4
Description		calcium modulating ligand	potassium voltage-gated channel subfamily E regulatory subunit 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane	Voltage-gated Potassium Channel Complex Apical Plasma Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Cell Adhesion Molecule Binding	Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Defense Response Signal Transduction Viral Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Stabilization	Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs		Cyclosporine	Enflurane Promethazine Miconazole
Diseases
GWAS		Height ( 18391951)	Acute lymphoblastic leukemia (childhood) ( 19684603) Body mass index ( 20966902) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Logical memory (delayed recall) in normal cognition ( 29274321) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Waist circumference ( 20966902) Weight ( 28552196)
Interacting Genes		22 interacting genes: ADIPOQ AGR2 EGFR ETNK1 F11R GET1 GET3 HSP90B1 KCNA2 KCNE4 LAT LCN2 OCIAD1 PBXIP1 PGRMC1 PKHD1 PPIB RPN1 TMEM31 TNFRSF13B TXNDC12 VWC2	10 interacting genes: CAMLG FLNA GET3 KCNA1 KCNQ1 OBSL1 PRKCA TCF7L2 TRDN TSNAX
Entrez ID		819	23704
HPRD ID		03073	09689
Ensembl ID		ENSG00000164615
Uniprot IDs		P49069	A5H1P5 Q8WWG9
PDB IDs		6SO5
Enriched GO Terms of Interacting Partners?
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