CDT1 and BAZ1B

Data Source:
BioGRID (pull down)

		CDT1	BAZ1B
Description		chromatin licensing and DNA replication factor 1	bromodomain adjacent to zinc finger domain 1B
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GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytosol Nuclear Body	Condensed Chromosome Nucleoplasm Pericentric Heterochromatin Nuclear Body Nuclear Replication Fork
	Molecular Function	DNA Binding Chromatin Binding Protein Binding DNA Polymerase Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Histone Kinase Activity Histone Binding
	Biological Process	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Chromosome Segregation Regulation Of DNA-dependent DNA Replication Initiation Positive Regulation Of Protein-containing Complex Assembly Regulation Of Chromosome Organization Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Chromatin Binding Positive Regulation Of DNA Replication Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization DNA Replication Preinitiation Complex Assembly Response To Sorbitol Deactivation Of Mitotic Spindle Assembly Checkpoint Regulation Of DNA Replication Origin Binding Negative Regulation Of Protein Localization To Kinetochore Positive Regulation Of Protein Localization To Kinetochore Positive Regulation Of DNA-dependent DNA Replication	Chromatin Assembly Or Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Histone Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Gene Expression, Epigenetic
Pathways		CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription	B-WICH complex positively regulates rRNA expression Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Glycated hemoglobin levels ( 28898252) Hair color ( 26926045) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010 20139978 28017375) Mean corpuscular volume ( 29403010)	C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Hypertriglyceridemia ( 23505323) Hyperuricemia ( 29124443) Lamb consumption ( 32066663) Malaria ( 31844061) Meat-related diet ( 32066663) Metabolic syndrome ( 31589552) Migraine ( 27182965) Non-oily fish consumption ( 32066663) Platelet count ( 32888494) Protein C levels ( 20802025) Pursuit maintenance gain ( 29064472) Serum uric acid levels ( 30993211) Triglyceride levels ( 32203549) Triglycerides ( 20864672) Urate levels ( 31985003 23263486) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		28 interacting genes: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK14 MCM2 MCM4 MCM6 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB	10 interacting genes: CDT1 MTNR1A MYO1C NR4A2 PCNA SMARCA1 SMARCA5 SMARCC2 SMARCE1 SUMO2
Entrez ID		81620	9031
HPRD ID		06900	10416
Ensembl ID		ENSG00000167513	ENSG00000009954
Uniprot IDs		Q9H211	Q9UIG0
PDB IDs		2LE8 2WVR 6QCG	1F62 5NNF
Enriched GO Terms of Interacting Partners?
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