CDT1 and ANAPC7

Data Source:
BioGRID (pull down)

		CDT1	ANAPC7
Description		chromatin licensing and DNA replication factor 1	anaphase promoting complex subunit 7
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GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytosol Nuclear Body	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Spindle Cytosol Microtubule Cytoskeleton
	Molecular Function	DNA Binding Chromatin Binding Protein Binding DNA Polymerase Binding	Protein Phosphatase Binding
	Biological Process	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Chromosome Segregation Regulation Of DNA-dependent DNA Replication Initiation Positive Regulation Of Protein-containing Complex Assembly Regulation Of Chromosome Organization Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Chromatin Binding Positive Regulation Of DNA Replication Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization DNA Replication Preinitiation Complex Assembly Response To Sorbitol Deactivation Of Mitotic Spindle Assembly Checkpoint Regulation Of DNA Replication Origin Binding Negative Regulation Of Protein Localization To Kinetochore Positive Regulation Of Protein Localization To Kinetochore Positive Regulation Of DNA-dependent DNA Replication	Ubiquitin-dependent Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Glycated hemoglobin levels ( 28898252) Hair color ( 26926045) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010 20139978 28017375) Mean corpuscular volume ( 29403010)	Bipolar disorder ( 31043756) QT interval ( 30679814) Schizophrenia ( 28991256) Total intracranial volume ( 31530798)
Interacting Genes		28 interacting genes: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK14 MCM2 MCM4 MCM6 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB	16 interacting genes: ANAPC10 ANAPC2 BUB1B CDC16 CDC20 CDC27 CDH1 CDT1 CREBBP FBXO5 FZR1 HSPB1 PTEN PTGER4 UBC UBE2S
Entrez ID		81620	51434
HPRD ID		06900	16233
Ensembl ID		ENSG00000167513	ENSG00000196510
Uniprot IDs		Q9H211	A0A024RBJ3 Q4KMX6 Q69YV3 Q9UJX3
PDB IDs		2LE8 2WVR 6QCG	3FFL 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5
Enriched GO Terms of Interacting Partners?
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