STMN4 and DIABLO

Data Source:
BioGRID (two hybrid)

		STMN4	DIABLO
Description		stathmin 4	diablo IAP-binding mitochondrial protein
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Growth Cone Neuron Projection	Mitochondrion Mitochondrial Intermembrane Space Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function	Tubulin Binding	Protein Binding
	Biological Process	Microtubule Depolymerization Regulation Of Microtubule Polymerization Or Depolymerization Neuron Projection Development	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway
Pathways			Release of apoptotic factors from the mitochondria SMAC (DIABLO) binds to IAPs SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Regulation of the apoptosome activity
Drugs		Lomustine 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE	Phenethyl Isothiocyanate
Diseases
GWAS		Bone mineral content ( 31790847) Bone mineral density ( 31790847)
Interacting Genes		15 interacting genes: ABHD16A AGTRAP CMTM3 DIABLO IMMT MALL MARCHF5 MTNR1B PHIP SEC22A SELENOK SNAPC5 STX8 TRAF3IP3 VSTM1	42 interacting genes: AGTRAP APOC2 APOC4 AREL1 ARL6IP1 ARNT BEX3 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP9 CMTM4 DERL2 DGAT2L6 DHRS1 E2F1 EEF1A1 FADS6 FKBP7 HSD17B13 HTRA2 LTBR MAML2 MICOS13 MPC2 NR4A1 RHBDD2 RMDN2 SEC22A SFT2D1 SLC17A9 SLC25A47 SLC66A2 STMN4 SYP TIMMDC1 UBE2K UFM1 XIAP ZNF746
Entrez ID		81551	56616
HPRD ID		18120	05560
Ensembl ID		ENSG00000015592	ENSG00000184047
Uniprot IDs		E7EVN3 Q9H169	A0A024RBT2 A0A0S2Z5P6 A0A0S2Z5U7 K7X1S0 Q502X2 Q9NR28
PDB IDs		6BR1 6BRF 6BRY 6NNG 6O5M 6O5N 6O61 6PC4	1FEW 1G3F 1G73 1OXQ 1TW6 1XB0 1XB1 3D9U 3UIH 3UIJ 4TX5 6JX6
Enriched GO Terms of Interacting Partners?
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