DIABLO and STMN4

Data Source:
BioGRID (two hybrid)

		DIABLO	STMN4
Description		diablo IAP-binding mitochondrial protein	stathmin 4
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Intermembrane Space Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex	Cytoplasm Golgi Apparatus Growth Cone Neuron Projection
	Molecular Function	Protein Binding	Tubulin Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway	Microtubule Depolymerization Regulation Of Microtubule Polymerization Or Depolymerization Neuron Projection Development
Pathways		Release of apoptotic factors from the mitochondria SMAC (DIABLO) binds to IAPs SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Regulation of the apoptosome activity
Drugs		Phenethyl Isothiocyanate	Lomustine 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS			Bone mineral content ( 31790847) Bone mineral density ( 31790847)
Interacting Genes		42 interacting genes: AGTRAP APOC2 APOC4 AREL1 ARL6IP1 ARNT BEX3 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP9 CMTM4 DERL2 DGAT2L6 DHRS1 E2F1 EEF1A1 FADS6 FKBP7 HSD17B13 HTRA2 LTBR MAML2 MICOS13 MPC2 NR4A1 RHBDD2 RMDN2 SEC22A SFT2D1 SLC17A9 SLC25A47 SLC66A2 STMN4 SYP TIMMDC1 UBE2K UFM1 XIAP ZNF746	15 interacting genes: ABHD16A AGTRAP CMTM3 DIABLO IMMT MALL MARCHF5 MTNR1B PHIP SEC22A SELENOK SNAPC5 STX8 TRAF3IP3 VSTM1
Entrez ID		56616	81551
HPRD ID		05560	18120
Ensembl ID		ENSG00000184047	ENSG00000015592
Uniprot IDs		A0A024RBT2 A0A0S2Z5P6 A0A0S2Z5U7 K7X1S0 Q502X2 Q9NR28	E7EVN3 Q9H169
PDB IDs		1FEW 1G3F 1G73 1OXQ 1TW6 1XB0 1XB1 3D9U 3UIH 3UIJ 4TX5 6JX6	6BR1 6BRF 6BRY 6NNG 6O5M 6O5N 6O61 6PC4
Enriched GO Terms of Interacting Partners?
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