THAP7 and PPP3CC

Data Source:
BioGRID (two hybrid)

		THAP7	PPP3CC
Description		THAP domain containing 7	protein phosphatase 3 catalytic subunit gamma
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Speck Nuclear Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Mitochondrion Cytosol Calcineurin Complex Presynapse Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Transcription Corepressor Binding DNA Binding Protein Binding Nucleosomal Histone Binding Methylated Histone Binding Identical Protein Binding Histone Deacetylase Binding Metal Ion Binding Protein N-terminus Binding Lysine-acetylated Histone Binding C2H2 Zinc Finger Domain Binding Phosphorylated Histone Binding General Transcription Initiation Factor Binding	Protein Binding Calmodulin Binding Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Negative Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated	Protein Dephosphorylation Brain Development Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways			Activation of BAD and translocation to mitochondria DARPP-32 events
Drugs
Diseases
GWAS			General risk tolerance (MTAG) ( 30643258) HIV-1 viral setpoint ( 20205591) Verbal declarative memory ( 25648963)
Interacting Genes		63 interacting genes: ANKRD28 APP CCDC136 CCDC85B CCNDBP1 CDC37 CYSRT1 DESI2 DVL3 EFEMP2 EHMT2 FBXO7 FHL3 FSD2 GABARAPL1 GNAI1 GOLGA2 GOLGA6L9 H3C1 H4C1 HCFC1 HDAC3 HOXA1 KRT27 KRT31 KRT34 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP17-1 KRTAP4-12 LDOC1 LNX1 LURAP1 LZTS2 MAGOHB MAP1LC3B MCC MDFI MID2 MTUS2 NBPF19 NOTCH2NLA NTAQ1 PELI2 PHC2 PHF19 PICK1 PIN1 PNMA2 PPP3CC SET TAF1B TFIP11 THAP11 TLE5 TPM3 TRAF1 TRAF2 TRAF5 ZDHHC17 ZRANB1	14 interacting genes: AMPH APP BCL2 BMPR1B CABIN1 CSNK2B HAX1 ITPKC PPP3R1 SDC2 SPATA33 TGFBR1 THAP7 UNC119
Entrez ID		80764	5533
HPRD ID		15500	00236
Ensembl ID		ENSG00000184436	ENSG00000120910
Uniprot IDs		Q9BT49	P48454
PDB IDs
Enriched GO Terms of Interacting Partners?
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