FOSL1 and ATF3

Data Source:
BioGRID (fluorescent resonance energy transfer)

		FOSL1	ATF3
Description		FOS like 1, AP-1 transcription factor subunit	activating transcription factor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Presynaptic Membrane Neuron Projection	Chromatin Nucleus Nucleoplasm Nucleolus CHOP-ATF3 Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	In Utero Embryonic Development Regulation Of Transcription By RNA Polymerase II Chemotaxis Cellular Defense Response Vitellogenesis Female Pregnancy Learning Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Mechanical Stimulus Response To Virus Response To Gravity Cellular Response To Extracellular Stimulus Response To Progesterone Response To Cytokine Response To Drug Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Cycle Positive Regulation Of DNA-binding Transcription Factor Activity Response To Corticosterone Response To CAMP Placenta Blood Vessel Development Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Initiation	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Cellular Response To Amino Acid Starvation Skeletal Muscle Cell Differentiation PERK-mediated Unfolded Protein Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription From RNA Polymerase II Promoter In Response To Arsenic-containing Substance Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		NGF-stimulated transcription NGF-stimulated transcription	ATF4 activates genes in response to endoplasmic reticulum stress Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs			Pseudoephedrine
Diseases
GWAS		Acne (severe) ( 24927181) Asthma ( 31959851) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 23128233) Psoriasis ( 28537254) Sum eosinophil basophil counts ( 27863252)	Blood cell traits (multivariate analysis) ( 31080455) Cerebral amyloid deposition (PET imaging) ( 26252872) Coronary artery disease ( 29212778) Thiopurine-induced leukopenia in inflammatory bowel disease (conditioned on rs116855232) ( 29923122)
Interacting Genes		30 interacting genes: ATF2 ATF3 ATF4 ATXN1 BATF3 CALCOCO1 CCDC120 CEBPA CEBPE CEBPG CREB5 DDIT3 DNMT3L EP300 ERCC6 GCC1 JUN JUNB KIFC3 KPNA1 LDOC1 MAF MAFB NME7 PARVG PIN1 TAB2 TRIM24 USF1 WFDC1	46 interacting genes: APPL2 ATF2 ATF4 BATF BATF3 CEBPA CEBPE CEBPG CREB3 CREBBP CRK DBP DDIT3 DNMT3L DOK5 FGFR3 FOS FOSL1 HDAC1 HDAC3 HDAC4 HDAC5 HDAC6 ID3 IGSF21 JUN JUND KAT5 LRIF1 MAFF MAFG NFKB1 NUF2 PDX1 POLR3D SH2D1A SMAD3 SRA1 SS18L1 STAT1 STAT3 SUV39H1 TP53 TP73 UBE2I ZNF212
Entrez ID		8061	467
HPRD ID		00643	04395
Ensembl ID		ENSG00000175592	ENSG00000162772
Uniprot IDs		A0A0S2Z595 E9PKL5 E9PPX2 P15407	P18847
PDB IDs
Enriched GO Terms of Interacting Partners?
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