PDHX and DLD

Data Source:
HPRD (in vitro)

		PDHX	DLD
Description		pyruvate dehydrogenase complex component X	dihydrolipoamide dehydrogenase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex	Nucleus Mitochondrion Mitochondrial Matrix Motile Cilium Acrosomal Matrix Oxoglutarate Dehydrogenase Complex Pyruvate Dehydrogenase Complex
	Molecular Function	Protein Binding Transferase Activity, Transferring Acyl Groups Pyruvate Dehydrogenase (NAD+) Activity	Dihydrolipoyl Dehydrogenase Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity Lipoamide Binding Flavin Adenine Dinucleotide Binding NAD Binding
	Biological Process	Pyruvate Metabolic Process Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate	Pyruvate Metabolic Process Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Mitochondrial Electron Transport, NADH To Ubiquinone Proteolysis Lysine Catabolic Process Gastrulation Aging Branched-chain Amino Acid Catabolic Process Lipoate Metabolic Process Regulation Of Membrane Potential Cell Redox Homeostasis Sperm Capacitation Dihydrolipoamide Metabolic Process Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate Histone Succinylation
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism	Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Glycine degradation Pyruvate metabolism Branched-chain amino acid catabolism Lysine catabolism Citric acid cycle (TCA cycle)
Drugs			NADH Flavin adenine dinucleotide
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome	Maple syrup urine disease (MSUD) Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Bone mineral density (hip) ( 30172743) Heel bone mineral density ( 30598549) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30297969) Uterine fibroids ( 30194396 31649266)	Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908 23128233 20228799 19122664) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		10 interacting genes: ACTN1 AGTRAP CIDEB DLAT DLD EP300 EWSR1 HSD17B10 PDHB PDK2	4 interacting genes: ITGB1BP1 OGDH PDHX SLC2A4
Entrez ID		8050	1738
HPRD ID		02002	02006
Ensembl ID		ENSG00000110435	ENSG00000091140
Uniprot IDs		O00330	A0A024R713 E9PEX6 P09622
PDB IDs		1ZY8 2DNC 2F5Z 2F60 6H60	1ZMC 1ZMD 1ZY8 2F5Z 3RNM 5J5Z 5NHG 6HG8 6I4P 6I4Q 6I4R 6I4S 6I4T 6I4U 6I4Z
Enriched GO Terms of Interacting Partners?
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