PDHX and DLAT

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		PDHX	DLAT
Description		pyruvate dehydrogenase complex component X	dihydrolipoamide S-acetyltransferase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex	Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Intracellular Membrane-bounded Organelle Pyruvate Dehydrogenase Complex
	Molecular Function	Protein Binding Transferase Activity, Transferring Acyl Groups Pyruvate Dehydrogenase (NAD+) Activity	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity Identical Protein Binding
	Biological Process	Pyruvate Metabolic Process Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Protein Phosphopantetheinylation Sleep
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism	Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism
Drugs			NADH Radicicol Dihydrolipoic Acid
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome	Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Bone mineral density (hip) ( 30172743) Heel bone mineral density ( 30598549) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30297969) Uterine fibroids ( 30194396 31649266)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		10 interacting genes: ACTN1 AGTRAP CIDEB DLAT DLD EP300 EWSR1 HSD17B10 PDHB PDK2	7 interacting genes: PDHA1 PDHX PDK1 PDK2 PDK3 PDK4 PRKD3
Entrez ID		8050	1737
HPRD ID		02002	10578
Ensembl ID		ENSG00000110435	ENSG00000150768
Uniprot IDs		O00330	P10515 Q86YI5
PDB IDs		1ZY8 2DNC 2F5Z 2F60 6H60	1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL 6CT0 6H55
Enriched GO Terms of Interacting Partners?
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