EDC3 and DCP1B

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		EDC3	DCP1B
Description		enhancer of mRNA decapping 3	decapping mRNA 1B
Image			No pdb structure
GO Annotations	Cellular Component	P-body Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule	P-body Nucleus Cytosol Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	MRNA Binding Protein Binding Identical Protein Binding Phosphodiesterase Decapping Endonuclease Activity	MRNA Binding Protein Binding Enzyme Activator Activity Hydrolase Activity Enzyme Regulator Activity
	Biological Process	Deadenylation-independent Decapping Of Nuclear-transcribed MRNA P-body Assembly Exonucleolytic Catabolism Of Deadenylated MRNA RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Catalytic Activity Exonucleolytic Catabolism Of Deadenylated MRNA
Pathways		mRNA decay by 5' to 3' exoribonuclease	mRNA decay by 5' to 3' exoribonuclease
Drugs
Diseases
GWAS		Caffeine consumption ( 21490707) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Coffee consumption (cups per day) ( 31837886) Craniofacial microsomia ( 26853712) Mean platelet volume ( 32888494)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Grapefruit juice consumption ( 31046077) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Response to gemcitabine in pancreatic cancer ( 22142827) Survival in pancreatic cancer ( 28470677)
Interacting Genes		11 interacting genes: ANXA10 DCP1B DDX6 EFHC2 LNX1 MIR15B PIAS2 QARS1 YWHAB YWHAG ZFP36	10 interacting genes: DCP2 EDC3 EXOSC6 LSM8 MIR15B NSMAF SMAD4 UPF2 XRN1 ZFP36
Entrez ID		80153	196513
HPRD ID		07954	13124
Ensembl ID		ENSG00000179151	ENSG00000151065
Uniprot IDs		Q96F86	B4DVJ6 Q8IZD4
PDB IDs		2VC8 2WAX 2WAY 3D3J 3D3K 6S8S
Enriched GO Terms of Interacting Partners?
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