DCP1B and EDC3

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		DCP1B	EDC3
Description		decapping mRNA 1B	enhancer of mRNA decapping 3
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytosol Membrane Intracellular Membrane-bounded Organelle	P-body Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	MRNA Binding Protein Binding Enzyme Activator Activity Hydrolase Activity Enzyme Regulator Activity	MRNA Binding Protein Binding Identical Protein Binding Phosphodiesterase Decapping Endonuclease Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Catalytic Activity Exonucleolytic Catabolism Of Deadenylated MRNA	Deadenylation-independent Decapping Of Nuclear-transcribed MRNA P-body Assembly Exonucleolytic Catabolism Of Deadenylated MRNA RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		mRNA decay by 5' to 3' exoribonuclease	mRNA decay by 5' to 3' exoribonuclease
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Grapefruit juice consumption ( 31046077) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Response to gemcitabine in pancreatic cancer ( 22142827) Survival in pancreatic cancer ( 28470677)	Caffeine consumption ( 21490707) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Coffee consumption (cups per day) ( 31837886) Craniofacial microsomia ( 26853712) Mean platelet volume ( 32888494)
Interacting Genes		10 interacting genes: DCP2 EDC3 EXOSC6 LSM8 MIR15B NSMAF SMAD4 UPF2 XRN1 ZFP36	11 interacting genes: ANXA10 DCP1B DDX6 EFHC2 LNX1 MIR15B PIAS2 QARS1 YWHAB YWHAG ZFP36
Entrez ID		196513	80153
HPRD ID		13124	07954
Ensembl ID		ENSG00000151065	ENSG00000179151
Uniprot IDs		B4DVJ6 Q8IZD4	Q96F86
PDB IDs			2VC8 2WAX 2WAY 3D3J 3D3K 6S8S
Enriched GO Terms of Interacting Partners?
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