CHMP6 and SNF8

Data Source:
HPRD (two hybrid)

		CHMP6	SNF8
Description		charged multivesicular body protein 6	SNF8 subunit of ESCRT-II
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GO Annotations	Cellular Component	ESCRT III Complex Multivesicular Body Cytosol Endosome Membrane Membrane Late Endosome Membrane Extracellular Exosome	ESCRT II Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane Endosome Membrane Membrane Late Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome
	Molecular Function	Protein Binding Protein-containing Complex Binding Protein N-terminus Binding	Protein Binding Protein C-terminus Binding Transcription Factor Binding Channel Regulator Activity Protein Homodimerization Activity Protein N-terminus Binding
	Biological Process	Vesicle Budding From Membrane Nucleus Organization Mitotic Metaphase Plate Congression Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Regulation Of Protein Catabolic Process Midbody Abscission Regulation Of Exosomal Secretion ESCRT III Complex Assembly	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Regulation Of Multivesicular Body Size Involved In Endosome Transport Endosomal Transport Macroautophagy Endocytic Recycling Multivesicular Body Assembly Regulation Of Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Regulation Of Protein Complex Stability Multivesicular Body Sorting Pathway Positive Regulation Of Exosomal Secretion Regulation Of Viral Budding Via Host ESCRT Complex
Pathways		Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
Drugs
Diseases
GWAS			Coronary heart disease ( 21378990) Type 2 diabetes ( 29358691)
Interacting Genes		7 interacting genes: CHMP4A CHMP4B ELOF1 METTL9 SNF8 VPS25 VPS36	24 interacting genes: ADORA1 AKAP9 CHMP6 CLP1 CT55 DVL2 ELL FANCL GLYCTK GOLGA2 KDM1A NIF3L1 PRMT6 RILP SMARCD1 SUOX SUV39H2 TRIM54 TSG101 TXLNA VAC14 VPS25 VPS36 YWHAE
Entrez ID		79643	11267
HPRD ID		08564	16847
Ensembl ID		ENSG00000176108	ENSG00000159210
Uniprot IDs		Q96FZ7	Q96H20
PDB IDs		2K3W 3HTU	2ZME 3CUQ
Enriched GO Terms of Interacting Partners?
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