MUL1 and UBXN7

Data Source:
BioGRID (enzymatic study)

		MUL1	UBXN7
Description		mitochondrial E3 ubiquitin protein ligase 1	UBX domain protein 7
Image
GO Annotations	Cellular Component	Mitochondrion Peroxisome Membrane Axon Integral Component Of Mitochondrial Outer Membrane Neuronal Cell Body	Nucleoplasm Cytosol Nuclear Body VCP-NPL4-UFD1 AAA ATPase Complex
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding
	Biological Process	Protein Polyubiquitination Mitochondrial Fission Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of JUN Kinase Activity Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Protein Ubiquitination Protein Sumoylation Negative Regulation Of Cell Growth Protein Destabilization Positive Regulation Of Protein Sumoylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus By Host Protein Stabilization Mitochondrion Localization Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Dendrite Extension Positive Regulation Of Autophagy Of Mitochondrion In Response To Mitochondrial Depolarization	Post-translational Protein Modification
Pathways		Ub-specific processing proteases	Neddylation
Drugs
Diseases
GWAS		Proportion of activated microglia (inferior temporal cortex) ( 30679421)	Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) IgM levels ( 28628107)
Interacting Genes		34 interacting genes: AKT1 APPBP2 CDC34 DNM1L EHD1 HTRA2 KRTAP10-8 MAP3K7 RANGAP1 REEP2 STING1 SUMO1 TAP1 TP53 TP73 TRIM9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2U UBE2V2 UBE2W UBXN7 ULK1	24 interacting genes: APP CLEC19A CRX CYSRT1 DAZAP2 FAM168A MAP3K1 MEOX1 MUL1 NEDD8 NFYC PAX5 PAX6 REL SMURF1 TRAF6 TRIM39 TRIM62 TRIM8 UBC UBQLN1 UBQLN2 VCP ZNRF1
Entrez ID		79594	26043
HPRD ID		07799	19396
Ensembl ID		ENSG00000090432	ENSG00000163960
Uniprot IDs		A1PUM0 Q969V5	O94888
PDB IDs		6K2K	1WJ4 2DAL 2DLX 5X3P 5X4L
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?