CENPO and ERI3

Data Source:
BioGRID (two hybrid)

		CENPO	ERI3
Description		centromere protein O	ERI1 exoribonuclease family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Kinetochore Nucleoplasm Cytosol Nuclear Body Mis6-Sim4 Complex
	Molecular Function	Protein Binding	3'-5'-exoribonuclease Activity RNA Binding Metal Ion Binding
	Biological Process	CENP-A Containing Nucleosome Assembly	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) DNA Catabolic Process, Exonucleolytic
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat mass ( 28552196) Body mass index ( 26426971 29273807) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cognitive function ( 28093568) Coronary artery disease ( 29212778) Height ( 28552196 25282103 23563607) Multiple sclerosis ( 24076602) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Trunk fat mass ( 28552196) Type 1 diabetes ( 21980299)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444)
Interacting Genes		7 interacting genes: CENPP CEP170P1 DCDC2 ERI3 FOS FOSB NECAB2	3 interacting genes: CENPO CPEB2 PRNP
Entrez ID		79172	79033
HPRD ID		14414	15175
Ensembl ID		ENSG00000138092	ENSG00000117419
Uniprot IDs		Q9BU64	B4DEX5 B4DN03 O43414
PDB IDs			2XRI
Enriched GO Terms of Interacting Partners?
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