VKORC1 and APOC3

Data Source:
BioGRID (two hybrid)

		VKORC1	APOC3
Description		vitamin K epoxide reductase complex subunit 1	apolipoprotein C3
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Early Endosome Very-low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding	Protein Binding Phospholipid Binding Cholesterol Binding Enzyme Regulator Activity Lipase Inhibitor Activity High-density Lipoprotein Particle Receptor Binding
	Biological Process	Blood Coagulation Response To Organonitrogen Compound Response To Organic Cyclic Compound Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Regulation Of Blood Coagulation Vitamin K Metabolic Process Response To Antibiotic Bone Development	Retinoid Metabolic Process Triglyceride Metabolic Process G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Triglyceride Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Low-density Lipoprotein Particle Clearance Triglyceride Catabolic Process Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux Chylomicron Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Lipoprotein Metabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Lipid Catabolic Process Negative Regulation Of Lipoprotein Lipase Activity Negative Regulation Of Cholesterol Import Triglyceride Homeostasis
Pathways		Metabolism of vitamin K	Chylomicron assembly Chylomicron remodeling HDL remodeling Retinoid metabolism and transport Retinoid metabolism and transport
Drugs		Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol	Copper Volanesorsen
Diseases		Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 20833655 19300499 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)	Blood protein levels ( 30072576) Body mass index ( 31978080) Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990) Delirium ( 29631748) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 28270201 20864672 19060906 30275531 20686565 26582766) HDL cholesterol levels ( 28334899) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 28548082) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 18179892 20864672 19060911 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 30576415 24386095) Lipoprotein (a) - cholesterol levels ( 25575512) Metabolite levels ( 22916037) Platelet count ( 27863252) Plateletcrit ( 32888494 27863252) Postprandial triglyceride levels ( 32603185) Red cell distribution width ( 32888494) Refractive error ( 32231278) Total cholesterol levels ( 28334899) Triglyceride levels ( 28334899 26763881 28371326 28548082) Triglycerides ( 19074352 21909109 18193043 18193044 20864672 19060906 19060911 20139978 20686565 26582766)
Interacting Genes		93 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL METTL7B MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24	6 interacting genes: ARFGAP1 ERGIC3 FAM209A GPX8 SOX4 VKORC1
Entrez ID		79001	345
HPRD ID		10540	00132
Ensembl ID		ENSG00000167397	ENSG00000110245
Uniprot IDs		A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6	A3KPE2 P02656
PDB IDs			2JQ3
Enriched GO Terms of Interacting Partners?
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