DUSP26 and HSF4

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		DUSP26	HSF4
Description		dual specificity phosphatase 26	heat shock transcription factor 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Extracellular Exosome	Chromatin Nucleus Nuclear Speck
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding P53 Binding Phosphoserine Phosphatase Activity Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Identical Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Cell Adhesion Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Peptidyl-serine Dephosphorylation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Visual Perception Positive Regulation Of Cell Population Proliferation Histone H3-K9 Demethylation Camera-type Eye Development Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development
Pathways
Drugs
Diseases
GWAS		Body mass index ( 28892062 25673413) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Metabolite levels ( 23823483) Morning person ( 30696823) Reading disability ( 32108986) Self-reported risk-taking behaviour ( 30271922)
Interacting Genes		11 interacting genes: CALCOCO2 CARD10 EPHA2 EPHA7 GOLGA6L9 GRIPAP1 HSF4 IGF1R KRT27 PTK7 RET	43 interacting genes: AKAP8L ALKBH4 C10orf55 C19orf54 CDK2AP2 DAXX DUSP26 FAM168B FOXH1 FOXI1 GFOD1 HGS INTS11 KRT31 KRT37 KRT38 KRT40 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP6-2 MAPK1 MAPK14 MAPK3 MAPK8 MKRN3 NHLRC4 NUDT21 NUP62 OIP5 PIH1D2 PITX1 PLA2G10 PPFIBP2 SESTD1 SLC27A5 SMARCA4 SOX10 TPM3 UFSP1 YTHDF1 ZBED8 ZMYND12
Entrez ID		78986	3299
HPRD ID		14421	03896
Ensembl ID		ENSG00000133878	ENSG00000102878
Uniprot IDs		Q9BV47	A0A024R6X7 Q9ULV5
PDB IDs		2E0T 4B04 4HRF 5GTJ	6J6V 6J6W
Enriched GO Terms of Interacting Partners?
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