USP7 and MDM4

  • Data Source:
  • BioGRID (pull down, x-ray crystallography, unspecified method)
  • HPRD (in vitro)

USP7

MDM4

Description ubiquitin specific peptidase 7 MDM4 regulator of p53
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GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Breast cancer ( 23535733 27117709)
  • Breast cancer (estrogen-receptor negative) ( 27117709 29058716)
  • Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915)
  • Breast Cancer in BRCA1 mutation carriers ( 23544013)
  • Cognitive performance ( 19734545)
  • Diastolic blood pressure ( 27618452 30578418)
  • Diastolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Eosinophil counts ( 32888494)
  • Eosinophil percentage of white cells ( 32888494)
  • Fish- and plant-related diet ( 32066663)
  • Glioma ( 28346443)
  • Levodopa wearing off effect (time symptoms uncontrolled) in Parkinson's disease (response to zonisamide) ( 32355309)
  • Non-glioblastoma glioma ( 28346443)
  • Oily fish consumption ( 32066663)
  • Pork consumption ( 32066663)
  • Prostate cancer ( 23535732)
  • Regular attendance at a religious group ( 29970889)
  • Systolic blood pressure ( 27618452)
  • Type 2 diabetes ( 32499647)
Interacting Genes 103 interacting genes: ABRAXAS2 ACD ANKS1A ANXA1 ARNT2 ATXN1 AXIN1 BCOR BEND5 CBX8 CLSPN CREB3L3 CRY1 CSNK2A1 DAXX DCTPP1 DNAJA3 DNMT3A ERCC6 EWSR1 FOXN2 GATA1 H2AC20 H2BU1 HECW1 HERPUD1 HIF1A HTRA2 HUWE1 IFNAR1 KAT5 KDM1A KLHL8 LINC02582 MAGEE1 MAL MARCHF7 MCMBP MDM2 MDM4 MYC MYD88 NECAB2 NOTCH1 OTUD4 PCGF2 PEG3 PEPD PHF8 PHLDB2 PICK1 PLA2G2A PLEKHO1 PLK1 PPARG PPL PSMD4 PTEN RAD18 RADIL RARA RB1 RBCK1 RELA RFFL RNF168 RNF220 SIRT7 SMAD3 SNCA SUMO2 SYVN1 TANK TBCB TFIP11 TMPO TP53 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO UBA52 UBC UBE2D3 UBE2E1 UBE2S USP21 USP28 VCP WWP2 XPC ZMYND8 ZNF423 ZNF76 63 interacting genes: AKT1 APP ARF1 ATM BECN1 C1orf109 CAPN7 CASP3 CBLC CD160 CD44 CDK1 CDK4 CDKN2A CDKN2B CHEK1 CHEK2 CSNK1A1 E2F1 EP300 EPHA2 FGFR4 GLIS2 HGF LATS2 LRSAM1 MAGEA1 MAP2K5 MDM2 MKRN3 MNAT1 NAA10 NF2 PELI1 PRKAA1 RAD54B RB1 RNF115 S100B SFN SMAD3 SMAD4 SMARCA2 TP53 TP63 TP73 TRIM46 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 USP7 VPS26C WDR5 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZKSCAN3 ZKSCAN4
Entrez ID 7874 4194
HPRD ID 03950 04082
Ensembl ID ENSG00000187555 ENSG00000198625
Uniprot IDs B7Z855 B7ZAX6 Q6U8A4 Q93009 A0A087WTR9 A0A087WUE3 A0A087WZ58 O15151 Q59FS6 Q68DC0
PDB IDs 1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ 4KG9 4M5W 4M5X 4PYZ 4WPH 4WPI 4YOC 4YSI 4Z96 4Z97 5C56 5C6D 5FWI 5GG4 5J7T 5JTJ 5JTV 5KYB 5KYC 5KYD 5KYE 5KYF 5N9R 5N9T 5NGE 5NGF 5UQV 5UQX 5VS6 5VSB 5VSK 5WHC 6F5H 6P5L 6VN2 6VN3 6VN4 6VN5 6VN6 7CM2 2CR8 2MWY 2N06 2N0U 2N0W 2N14 2VJE 2VJF 2VYR 3DAB 3EQY 3FDO 3FE7 3FEA 3JZO 3JZP 3JZQ 3LBJ 3MQR 3U15 4RXZ 5MNJ 5UML 5VK1 6Q9Q 6Q9S 6Q9U 6Q9W 6Q9Y 7C3Q 7C3Y 7C44
Enriched GO Terms of Interacting Partners?
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