MDM4 and ZKSCAN3

Data Source:
BioGRID (two hybrid)

		MDM4	ZKSCAN3
Description		MDM4 regulator of p53	zinc finger with KRAB and SCAN domains 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Zinc Ion Binding Enzyme Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Ventricular Septum Development Atrial Septum Development Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Cell Population Proliferation Protein Deubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Protein-containing Complex Assembly Negative Regulation Of Cell Cycle Arrest Cellular Response To Hypoxia Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Autophagy Lysosome Organization Negative Regulation Of Autophagy Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Senescence
Pathways		Oxidative Stress Induced Senescence Oncogene Induced Senescence Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53	Generic Transcription Pathway
Drugs
Diseases
GWAS		Breast cancer ( 23535733 27117709) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 23544013) Cognitive performance ( 19734545) Diastolic blood pressure ( 27618452 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Fish- and plant-related diet ( 32066663) Glioma ( 28346443) Levodopa wearing off effect (time symptoms uncontrolled) in Parkinson's disease (response to zonisamide) ( 32355309) Non-glioblastoma glioma ( 28346443) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 23535732) Regular attendance at a religious group ( 29970889) Systolic blood pressure ( 27618452) Type 2 diabetes ( 32499647)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213) Lung function (FVC) ( 28166213) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Pulmonary function ( 21946350) Refractive error ( 32231278) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 28991256) Sleep duration (short sleep) ( 30846698) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		63 interacting genes: AKT1 APP ARF1 ATM BECN1 C1orf109 CAPN7 CASP3 CBLC CD160 CD44 CDK1 CDK4 CDKN2A CDKN2B CHEK1 CHEK2 CSNK1A1 E2F1 EP300 EPHA2 FGFR4 GLIS2 HGF LATS2 LRSAM1 MAGEA1 MAP2K5 MDM2 MKRN3 MNAT1 NAA10 NF2 PELI1 PRKAA1 RAD54B RB1 RNF115 S100B SFN SMAD3 SMAD4 SMARCA2 TP53 TP63 TP73 TRIM46 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 USP7 VPS26C WDR5 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZKSCAN3 ZKSCAN4	8 interacting genes: GOLGA6L9 IHO1 LZTS2 MDM4 MEOX2 PDE4DIP SCAND1 TRAF2
Entrez ID		4194	80317
HPRD ID		04082	11705
Ensembl ID		ENSG00000198625	ENSG00000189298
Uniprot IDs		A0A087WTR9 A0A087WUE3 A0A087WZ58 O15151 Q59FS6 Q68DC0	Q9BRR0
PDB IDs		2CR8 2MWY 2N06 2N0U 2N0W 2N14 2VJE 2VJF 2VYR 3DAB 3EQY 3FDO 3FE7 3FEA 3JZO 3JZP 3JZQ 3LBJ 3MQR 3U15 4RXZ 5MNJ 5UML 5VK1 6Q9Q 6Q9S 6Q9U 6Q9W 6Q9Y 7C3Q 7C3Y 7C44
Enriched GO Terms of Interacting Partners?
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