MAPKAPK3 and MAPK13

Data Source:
BioGRID (imaging technique)
HPRD (in vitro)

		MAPKAPK3	MAPK13
Description		MAPK activated protein kinase 3	mitogen-activated protein kinase 13
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Toll-like Receptor Signaling Pathway Signal Transduction Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Response To Cytokine Intracellular Signal Transduction Macropinocytosis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway	Response To Osmotic Stress Cell Cycle Peptidyl-serine Phosphorylation Positive Regulation Of Interleukin-6 Production Cellular Response To UV Intracellular Signal Transduction Positive Regulation Of Inflammatory Response Stress-activated MAPK Cascade Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Sorbitol Cellular Response To Anisomycin Cellular Response To Sodium Arsenite
Pathways		p38MAPK events Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation	NOD1/2 Signaling Pathway p38MAPK events DSCAM interactions VEGFA-VEGFR2 Pathway
Drugs		2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE	Minocycline KC706 Fostamatinib
Diseases
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) High light scatter reticulocyte count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Birth weight ( 31043758) Blood protein levels ( 30072576 29875488) Offspring birth weight ( 31043758)
Interacting Genes		21 interacting genes: APP ATF1 BECN1 COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM LINC02582 MAPK13 MAPK14 NEDD4 NEDD4L RAB2A RCSD1 SMS SRPK2 SUMO3 TCF3 THAP12	16 interacting genes: AKIP1 ANKLE2 APP ATF2 EEF2K FGF12 GPX4 HTRA2 MAP2K6 MAP3K4 MAPKAPK3 MAPKAPK5 MAPT MBP SMAD4 SQSTM1
Entrez ID		7867	5603
HPRD ID		03678	09113
Ensembl ID		ENSG00000114738	ENSG00000156711
Uniprot IDs		A0A024R2W7 Q16644	A0A024RD04 O15264
PDB IDs		3FHR 3FXW 3R1N 3SHE	3COI 4EYJ 4EYM 4MYG 4YNO 5EKN 5EKO
Enriched GO Terms of Interacting Partners?
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