MAPKAPK3 and ATF1

Data Source:
BioGRID (enzymatic study)

		MAPKAPK3	ATF1
Description		MAPK activated protein kinase 3	activating transcription factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex ATF4-CREB1 Transcription Factor Complex ATF1-ATF4 Transcription Factor Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity
	Biological Process	MAPK Cascade Activation Of MAPK Activity Toll-like Receptor Signaling Pathway Signal Transduction Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Response To Cytokine Intracellular Signal Transduction Macropinocytosis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Projection Development Response To Organic Cyclic Compound Response To Cobalt Ion Cellular Protein-containing Complex Assembly Positive Regulation Of DNA Replication Positive Regulation Of Transcription By RNA Polymerase II
Pathways		p38MAPK events Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation	CREB phosphorylation NGF-stimulated transcription NGF-stimulated transcription
Drugs		2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE	Pseudoephedrine
Diseases			Clear cell sarcoma of soft tissue
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) High light scatter reticulocyte count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Apolipoprotein A1 levels ( 32203549) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Colorectal cancer ( 25990418 20972440 24737748) Colorectal cancer or advanced adenoma ( 30510241) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) HDL cholesterol levels ( 32203549) Male-pattern baldness ( 27182965) Mean arterial pressure ( 27618448) Multiple sclerosis ( 31604244) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 30578418)
Interacting Genes		21 interacting genes: APP ATF1 BECN1 COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM LINC02582 MAPK13 MAPK14 NEDD4 NEDD4L RAB2A RCSD1 SMS SRPK2 SUMO3 TCF3 THAP12	23 interacting genes: BRCA1 CAMK1 CAMK2A CAMK2G CREB1 CREBBP CREM CSNK2A1 CSNK2A2 CSNK2B DNMT3L EDF1 GABPA GABPB1 HNF1B JUN MAPKAPK2 MAPKAPK3 PRKACA RPS6KA4 RPS6KA5 SPI1 SRA1
Entrez ID		7867	466
HPRD ID		03678	00440
Ensembl ID		ENSG00000114738	ENSG00000123268
Uniprot IDs		A0A024R2W7 Q16644	P18846
PDB IDs		3FHR 3FXW 3R1N 3SHE
Enriched GO Terms of Interacting Partners?
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