ZBTB17 and HK2

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		ZBTB17	HK2
Description		zinc finger and BTB domain containing 17	hexokinase 2
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GO Annotations	Cellular Component	Nucleoplasm Protein-containing Complex Protein-DNA Complex	Mitochondrion Mitochondrial Outer Membrane Centrosome Cytosol Plasma Membrane Membrane Sarcoplasmic Reticulum Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Metal Ion Binding	Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gastrulation With Mouth Forming Second Regulation Of Transcription By RNA Polymerase II Ectoderm Development Negative Regulation Of Cell Population Proliferation IRE1-mediated Unfolded Protein Response Negative Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Cycle Arrest	Response To Hypoxia Cellular Glucose Homeostasis Response To Ischemia Fructose 6-phosphate Metabolic Process Glycolytic Process Lactation Apoptotic Mitochondrial Changes Negative Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Angiogenesis Regulation Of Glucose Import Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Positive Regulation Of Autophagy Of Mitochondrion In Response To Mitochondrial Depolarization Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		XBP1(S) activates chaperone genes	Glycolysis
Drugs
Diseases
GWAS		Erectile dysfunction ( 30583798) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Idiopathic dilated cardiomyopathy ( 21459883)	Femoral neck bone geometry ( 22087292)
Interacting Genes		27 interacting genes: BCL6 CDKN2B CREBBP DIS3 DNMT3A E2F6 EP300 ESR1 ESR2 GTF2I HCFC1 HK2 HK3 HSPB1 IRF8 ITGB5 MAX MSX2 MYC MYCN PGR TMPRSS11A TOPBP1 TRIM55 TRIM63 ZBTB7C ZBTB8A	9 interacting genes: ENO1 MAGEA12 PRKCE PTGDS SLC2A4 SUMO2 UBQLN1 UBQLN4 ZBTB17
Entrez ID		7709	3099
HPRD ID		04968	03080
Ensembl ID		ENSG00000116809	ENSG00000159399
Uniprot IDs		Q13105 Q53EM1	P52789
PDB IDs		2LVR 2LVT 2LVU 2M0D 2M0E 2M0F 2N25 2N26 2Q81 3M52 4U2M 4U2N 5ION	2NZT 5HEX 5HFU 5HG1
Enriched GO Terms of Interacting Partners?
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