ZBTB17 and DIS3

Data Source:
HPRD (two hybrid)

		ZBTB17	DIS3
Description		zinc finger and BTB domain containing 17	DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
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GO Annotations	Cellular Component	Nucleoplasm Protein-containing Complex Protein-DNA Complex	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Metal Ion Binding	3'-5'-exoribonuclease Activity RNA Binding Endonuclease Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gastrulation With Mouth Forming Second Regulation Of Transcription By RNA Polymerase II Ectoderm Development Negative Regulation Of Cell Population Proliferation IRE1-mediated Unfolded Protein Response Negative Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Cycle Arrest	RRNA Processing RRNA Catabolic Process Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA Regulation Of Catalytic Activity CUT Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		XBP1(S) activates chaperone genes	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Erectile dysfunction ( 30583798) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Idiopathic dilated cardiomyopathy ( 21459883)	Restless legs syndrome ( 29029846)
Interacting Genes		27 interacting genes: BCL6 CDKN2B CREBBP DIS3 DNMT3A E2F6 EP300 ESR1 ESR2 GTF2I HCFC1 HK2 HK3 HSPB1 IRF8 ITGB5 MAX MSX2 MYC MYCN PGR TMPRSS11A TOPBP1 TRIM55 TRIM63 ZBTB7C ZBTB8A	12 interacting genes: EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MTREX NTMT1 PALS2 ZBTB17
Entrez ID		7709	22894
HPRD ID		04968	06338
Ensembl ID		ENSG00000116809	ENSG00000083520
Uniprot IDs		Q13105 Q53EM1	G3V1J5 Q9Y2L1
PDB IDs		2LVR 2LVT 2LVU 2M0D 2M0E 2M0F 2N25 2N26 2Q81 3M52 4U2M 4U2N 5ION	6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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