ZBTB25 and FCGR3A

Data Source:
BioGRID (two hybrid)

		ZBTB25	FCGR3A
Description		zinc finger and BTB domain containing 25	Fc fragment of IgG receptor IIIa
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding	Transmembrane Signaling Receptor Activity IgG Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Immune Response Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune Response
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs			Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Alefacept Palivizumab Daclizumab Bevacizumab Catumaxomab Sarilumab Benralizumab
Diseases			NK cell defects, including the following disease: CD16 deficiency Systemic lupus erythematosus
GWAS		Heel bone mineral density ( 30598549) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 32888494 27863252)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 31043758) Blood protein levels ( 28240269) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Hematocrit ( 32888494) Hemoglobin ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Monocyte percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 30498034 23830517) Ulcerative colitis ( 28067908)
Interacting Genes		34 interacting genes: APIP COIL CRACR2B CYP2J2 CYSRT1 DDIT3 FCGR3A FHL2 HCLS1 HOMEZ HSBP1 KCTD1 KCTD9 KRTAP10-8 KRTAP17-1 KXD1 LZTS2 MAPK9 MDFI PCBD1 PNMA5 SEPHS1 SORBS3 SSX3 SUMO2 TBC1D5 TNIP1 TRAF2 TRAF6 TSSK3 VCP VMAC ZBTB1 ZBTB2	19 interacting genes: APCS APP CD247 CD38 CD4 FCER1G FCGR1A GP6 IGHG1 LCK LXN PRKCA PRKCI PTPRC S100A4 SHC1 SYK ZAP70 ZBTB25
Entrez ID		7597	2214
HPRD ID		01926	00903
Ensembl ID		ENSG00000089775	ENSG00000203747
Uniprot IDs		G3V2K3 P24278	H0Y755 P08637
PDB IDs			3AY4 3SGJ 3SGK 3WN5 5BW7 5D6D 5ML9 5MN2 5VU0 5XJE 5XJF 5YC5
Enriched GO Terms of Interacting Partners?
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