TMEM50B and HLA-DPA1

Data Source:
BioGRID (two hybrid)

		TMEM50B	HLA-DPA1
Description		transmembrane protein 50B	major histocompatibility complex, class II, DP alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Intracellular Membrane-bounded Organelle Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Molecular_function Protein Binding	MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Biological_process Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway	Adaptive Immune Response Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma
Pathways			Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs
Diseases			Dilated cardiomyopathy (DCM)
GWAS		Crohn's disease ( 23128233) Educational attainment ( 25201988)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Asthma ( 30929738 31619474) Asthma (childhood onset) ( 30929738) Autism spectrum disorder or schizophrenia ( 28540026) Chronic hepatitis B infection ( 25802187) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Hepatitis B ( 21750111) Hepatitis B (viral clearance) ( 22737229) IgA nephropathy ( 25305756) Keratinocyte cancer (MTAG) ( 31174203) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) Mortality in sepsis ( 27639821) Myositis ( 26291516) Nephropathy ( 21399633) Pulmonary arterial hypertension ( 30527956) Response to hepatitis B vaccine ( 29534301) SjÃ¶gren's syndrome ( 24097066) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533)
Interacting Genes		21 interacting genes: AMIGO1 BCL2L1 CLRN1 CREB3L1 EDA FAM209A FXYD3 GPR152 GPX8 HLA-DPA1 LEPROTL1 LHFPL5 NCR1 SCN3B SLC10A6 SLC16A13 SLC35C2 TMEM14B TMEM52B TMEM88 TMX2	6 interacting genes: CD4 CD74 CNMD HLA-DPB1 TMEM50A TMEM50B
Entrez ID		757	3113
HPRD ID		10747	00835
Ensembl ID		ENSG00000142188	ENSG00000231389
Uniprot IDs		P56557	P20036 X5CKE2
PDB IDs			3LQZ 4P4K 4P4R 4P57 4P5K 4P5M
Enriched GO Terms of Interacting Partners?
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