YWHAH and CHRNA4

Data Source:
BioGRID (two hybrid)
HPRD (in vivo)

		YWHAH	CHRNA4
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta	cholinergic receptor nicotinic alpha 4 subunit
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Intercalated Disc Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Membrane Integral Component Of Membrane Dendrite Neuron Projection Neuronal Cell Body Synapse Postsynaptic Membrane
	Molecular Function	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Identical Protein Binding Ion Channel Binding Protein Heterodimerization Activity	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding
	Biological Process	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Substantia Nigra Development Glucocorticoid Receptor Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Organization Membrane Depolarization During Action Potential Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity	Action Potential Response To Hypoxia DNA Repair Ion Transport Calcium Ion Transport Response To Oxidative Stress Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Regulation Of Dopamine Secretion Sensory Perception Of Pain Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine B Cell Activation Regulation Of Membrane Potential Nervous System Process Cognition Membrane Depolarization Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Phenethyl Isothiocyanate	Nicotine Butabarbital Butalbital Talbutal Pentobarbital Methadone Secobarbital Metharbital Dextromethorphan Carbamazepine Atropine Thiopental Mecamylamine Scopolamine Isoflurane Estradiol Primidone Methylphenobarbital Ethanol Amantadine Physostigmine Phenobarbital Decamethonium Varenicline Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Pozanicline RPI-78M Epibatidine Cytisine Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
Diseases			Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)
GWAS		Post bronchodilator FEV1 ( 26634245) Type 2 diabetes ( 30297969)	Chronic obstructive pulmonary disease ( 19300482) Emphysema imaging phenotypes ( 26030696) Nicotine dependence ( 28972577 26440539) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking behaviour (cigarettes smoked per day) ( 30617275 30679032) Smoking status (heavy vs never) ( 26423011)
Interacting Genes		66 interacting genes: ABL1 ARHGEF28 BAD BCR BRAF CCDC125 CDC25B CDC25C CDC42 CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 HSPB1 ING1 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KIF5B KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCOA1 NCOA2 NCOA3 NEK1 NHSL2 NR3C1 NRIP1 PARD3 PARD6A PARD6B PDPK1 PRKCI PRKN PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36	8 interacting genes: CHRNB2 CHRNB4 CRELD2 CSNK2B RHOU UBQLN1 VSNL1 YWHAH
Entrez ID		7533	1137
HPRD ID		00215	00333
Ensembl ID		ENSG00000128245	ENSG00000101204
Uniprot IDs		A0A024R1K7 Q04917 Q9H4N8	B4DK78 P43681 Q4VAQ3 Q59FV0
PDB IDs		2C63 2C74	2GVT 2LLY 5KXI 6CNJ 6CNK 6UR8 6USF
Enriched GO Terms of Interacting Partners?
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