CHRNA4 and CHRNB2

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		CHRNA4	CHRNB2
Description		cholinergic receptor nicotinic alpha 4 subunit	cholinergic receptor nicotinic beta 2 subunit
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Membrane Integral Component Of Membrane Dendrite Neuron Projection Neuronal Cell Body Synapse Postsynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex External Side Of Plasma Membrane Integral Component Of Membrane Neuron Projection Plasma Membrane Raft Synapse Postsynaptic Membrane
	Molecular Function	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding
	Biological Process	Action Potential Response To Hypoxia DNA Repair Ion Transport Calcium Ion Transport Response To Oxidative Stress Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Regulation Of Dopamine Secretion Sensory Perception Of Pain Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine B Cell Activation Regulation Of Membrane Potential Nervous System Process Cognition Membrane Depolarization Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential	Response To Hypoxia Ion Transport Calcium Ion Transport Smooth Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Visual Perception Sensory Perception Of Sound Learning Memory Locomotory Behavior Associative Learning Visual Learning Regulation Of Dopamine Secretion Sensory Perception Of Pain Vestibulocochlear Nerve Development Optic Nerve Morphogenesis Lateral Geniculate Nucleus Development Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of B Cell Proliferation Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Dopamine Secretion Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Social Behavior Regulation Of Dopamine Metabolic Process B Cell Activation Response To Cocaine Regulation Of Circadian Sleep/wake Cycle, REM Sleep Regulation Of Membrane Potential Response To Ethanol Negative Regulation Of Action Potential Regulation Of Dendrite Morphogenesis Nervous System Process Cognition Membrane Depolarization Regulation Of Synapse Assembly Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition Acetylcholine Receptor Signaling Pathway Response To Acetylcholine
Pathways		Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Nicotine Butabarbital Butalbital Talbutal Pentobarbital Methadone Secobarbital Metharbital Dextromethorphan Carbamazepine Atropine Thiopental Mecamylamine Scopolamine Isoflurane Estradiol Primidone Methylphenobarbital Ethanol Amantadine Physostigmine Phenobarbital Decamethonium Varenicline Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Pozanicline RPI-78M Epibatidine Cytisine Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate	Nicotine Butabarbital Methadone Dextromethorphan Atropine Mecamylamine Scopolamine Isoflurane Ethanol Physostigmine Decamethonium Varenicline Pozanicline RPI-78M Rivanicline Epibatidine Cytisine
Diseases		Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)	Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)
GWAS		Chronic obstructive pulmonary disease ( 19300482) Emphysema imaging phenotypes ( 26030696) Nicotine dependence ( 28972577 26440539) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking behaviour (cigarettes smoked per day) ( 30617275 30679032) Smoking status (heavy vs never) ( 26423011)	Nicotine dependence ( 28440896) Smoking behaviour (cigarettes smoked per day) ( 30679032)
Interacting Genes		8 interacting genes: CHRNB2 CHRNB4 CRELD2 CSNK2B RHOU UBQLN1 VSNL1 YWHAH	3 interacting genes: CHRNA2 CHRNA4 CRELD2
Entrez ID		1137	1141
HPRD ID		00333	00335
Ensembl ID		ENSG00000101204	ENSG00000160716
Uniprot IDs		B4DK78 P43681 Q4VAQ3 Q59FV0	P17787 Q5SXY3
PDB IDs		2GVT 2LLY 5KXI 6CNJ 6CNK 6UR8 6USF	2GVT 2K58 2K59 2KSR 2LM2 5KXI 6CNJ 6CNK 6UR8 6USF
Enriched GO Terms of Interacting Partners?
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