XPO1 and EIF5A

Data Source:
HPRD (in vitro)

		XPO1	EIF5A
Description		exportin 1	eukaryotic translation initiation factor 5A
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Host Cell Ribonucleoprotein Complex	Nucleus Annulate Lamellae Nuclear Pore Cytoplasm Endoplasmic Reticulum Membrane Cytosol Membrane
	Molecular Function	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding	RNA Binding Translation Elongation Factor Activity Protein Binding U6 SnRNA Binding Ribosome Binding Protein N-terminus Binding
	Biological Process	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Protein Export From Nucleus Nucleocytoplasmic Transport Viral Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ribosome Biogenesis Regulation Of MRNA Stability MRNA Transport Intracellular Transport Of Virus	MRNA Export From Nucleus Translational Elongation Protein Export From Nucleus Nucleocytoplasmic Transport Apoptotic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation	Hypusine synthesis from eIF5A-lysine
Drugs		Selinexor
Diseases
GWAS		Atrial fibrillation ( 29892015) Eosinophil counts ( 32888494 27863252) Erectile dysfunction ( 30583798) Mean reticulocyte volume ( 32888494) Neutrophil count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Urinary sodium excretion ( 31409800) White blood cell count ( 32888494)	Venous thromboembolism ( 31420334)
Interacting Genes		80 interacting genes: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 BRCA2 CCND1 CDC25A CDC42 CDCA4 CDKN1B CHEK1 CHORDC1 CIITA CRK DDX3X DESI1 DR1 E2F4 E2F5 EIF5A ERF FBXO7 FOXO4 HDAC3 HNF4A HSPA9 HSPB1 IRF5 KIF17 LINC01554 MAPK6 NF2 NMD3 NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 ORC1 PHAX PHB PKIA RAD51 RAN RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SMURF2 SNUPN SOX2 STAT1 STRADA SUMO1 SUMO2 TERF2IP TERT TOP2A TOP2B TP53 TP73	17 interacting genes: CRX DHPS DOHH GSC2 LBX1 MEI4 MEOX2 PICK1 REL RPL5 SDCBP STUB1 SUMO2 TGM2 XPO1 XPO4 XRN2
Entrez ID		7514	1984
HPRD ID		03975	02555
Ensembl ID		ENSG00000082898	ENSG00000132507
Uniprot IDs		B3KWD0 O14980	P63241
PDB IDs		1W9C 2L1L 3GB8 4BSM 4BSN 5DIS 6TVO	1FH4 3CPF 5DLQ
Enriched GO Terms of Interacting Partners?
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