XDH and BTN1A1

Data Source:
HPRD (in vivo)

		XDH	BTN1A1
Description		xanthine dehydrogenase	butyrophilin subfamily 1 member A1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Peroxisome Cytosol Sarcoplasmic Reticulum	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Xanthine Dehydrogenase Activity Xanthine Oxidase Activity Iron Ion Binding Protein Binding Electron Transfer Activity Oxidoreductase Activity Protein Homodimerization Activity Molybdopterin Cofactor Binding Flavin Adenine Dinucleotide Binding 2 Iron, 2 Sulfur Cluster Binding Hypoxanthine Dehydrogenase Activity Hypoxanthine Oxidase Activity FAD Binding	Signaling Receptor Binding Protein Binding Signaling Receptor Activity
	Biological Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Endothelial Cell Proliferation Purine Nucleotide Catabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Lactation Xanthine Catabolic Process Negative Regulation Of Gene Expression Electron Transport Chain Negative Regulation Of Endothelial Cell Differentiation GMP Catabolic Process DGMP Catabolic Process Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of P38MAPK Cascade Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Vasculogenesis	Regulation Of Cytokine Production T Cell Receptor Signaling Pathway
Pathways		Purine catabolism Butyrophilin (BTN) family interactions	Butyrophilin (BTN) family interactions
Drugs		Allopurinol Levocarnitine Topiroxostat Flavin adenine dinucleotide Dioxo(sulfanyl)molybdenum Eniluracil Niraxostat Febuxostat Oxypurinol
Diseases		Xanthinuria
GWAS		Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Male-pattern baldness ( 28196072) Multiple system atrophy ( 27629089) Obesity-related traits ( 23251661) Parahippocampal gyrus volume ( 31530798) Periventricular white matter hyperintensities ( 32517579) Zinc levels ( 26025379)	Age at first sexual intercourse ( 27089180) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Educational attainment (years of education) ( 23722424) Fish- and plant-related diet ( 32066663) Gastroesophageal reflux disease ( 31527586) Intelligence (MTAG) ( 29326435) Iron status biomarkers ( 19084217) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Weight ( 28552196)
Interacting Genes		2 interacting genes: BTN1A1 GRIP1	3 interacting genes: MEOX2 MOSPD2 XDH
Entrez ID		7498	696
HPRD ID		06363	03365
Ensembl ID		ENSG00000158125	ENSG00000124557
Uniprot IDs		P47989	Q13410 Q4VAN2
PDB IDs		2CKJ 2E1Q
Enriched GO Terms of Interacting Partners?
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