XDH

Description		xanthine dehydrogenase
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GO Annotations	Cellular Component	Extracellular Space Peroxisome Cytosol Sarcoplasmic Reticulum
	Molecular Function	Xanthine Dehydrogenase Activity Xanthine Oxidase Activity Iron Ion Binding Protein Binding Electron Transfer Activity Oxidoreductase Activity Protein Homodimerization Activity Molybdopterin Cofactor Binding Flavin Adenine Dinucleotide Binding 2 Iron, 2 Sulfur Cluster Binding Hypoxanthine Dehydrogenase Activity Hypoxanthine Oxidase Activity FAD Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Endothelial Cell Proliferation Purine Nucleotide Catabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Lactation Xanthine Catabolic Process Negative Regulation Of Gene Expression Electron Transport Chain Negative Regulation Of Endothelial Cell Differentiation GMP Catabolic Process DGMP Catabolic Process Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of P38MAPK Cascade Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Vasculogenesis
Pathways		Purine catabolism Butyrophilin (BTN) family interactions
Drugs		Allopurinol Levocarnitine Topiroxostat Flavin adenine dinucleotide Dioxo(sulfanyl)molybdenum Eniluracil Niraxostat Febuxostat Oxypurinol
Diseases		Xanthinuria
GWAS		Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Male-pattern baldness ( 28196072) Multiple system atrophy ( 27629089) Obesity-related traits ( 23251661) Parahippocampal gyrus volume ( 31530798) Periventricular white matter hyperintensities ( 32517579) Zinc levels ( 26025379)
Interacting Genes		2 interacting genes: BTN1A1 GRIP1
Entrez ID		7498
HPRD ID		06363
Ensembl ID		ENSG00000158125
Uniprot IDs		P47989
PDB IDs		2CKJ 2E1Q
Enriched GO Terms of Interacting Partners?
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