UBE2D3 and RPLP1

Data Source:
BioGRID (two hybrid)

		UBE2D3	RPLP1
Description		ubiquitin conjugating enzyme E2 D3	ribosomal protein lateral stalk subunit P1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Endosome Membrane Extracellular Exosome	Cytosol Focal Adhesion Cytosolic Large Ribosomal Subunit
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Structural Constituent Of Ribosome Protein Binding Protein Kinase Activator Activity Ribonucleoprotein Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination MyD88-independent Toll-like Receptor Signaling Pathway DNA Repair Cellular Protein Modification Process Protein Monoubiquitination Protein Targeting To Peroxisome Apoptotic Process Protein Ubiquitination BMP Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Response To Cadmium Ion Cellular Response To Mercury Ion Positive Regulation Of Protein Targeting To Mitochondrion	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Translation Translational Initiation Translational Elongation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Activation Of Protein Kinase Activity
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Antigen processing: Ubiquitination & Proteasome degradation	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Asthma and attention deficit hyperactivity disorder ( 31619474) Diastolic blood pressure ( 30224653)	Chronic lymphocytic leukemia ( 28165464 24292274 23770605) Male-pattern baldness ( 27182965) Non-response to citalopram or escitalopram and depression ( 27622933)
Interacting Genes		224 interacting genes: AMBRA1 AMFR ANAPC11 AREL1 ARIH1 ARIH2 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRCA1 CADPS2 CBL CBLC CHFR CNOT4 CSNK2A1 CUL4B DBN1 DCUN1D1 DDX58 DTX1 DTX2 DTX3 DTX3L DVL2 DZIP3 EPS15 ERGIC3 ESR1 F12 FBXL12 FBXL17 FBXL2 FBXO2 FBXO25 FBXO7 FBXW11 FBXW8 FOCAD FZR1 H2AC4 H3C1 H4C1 HDAC6 HECTD1 HECW1 HECW2 HERC1 HERC2 HUWE1 IKBKG ITCH KAT2B KDM1B LRSAM1 MAEA MAP3K1 MAPT MARCHF3 MARCHF5 MARCHF7 MARCHF8 MAST1 MDM2 MDM4 MEX3B MEX3C MGRN1 MIB1 MID1 MID2 MKRN1 MKRN3 MSL1 MSL2 MUL1 MYCBP2 MYLIP NBR1 NEDD4 NEDD4L NFKB1 NFKBIA NHLRC1 NOSIP OTUB1 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PCNA PDCD5 PELI1 PER2 PJA1 PJA2 POLL POLM PRPF19 PTEN RABGEF1 RBCK1 RBX1 RCHY1 RELA RFFL RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF111 RNF114 RNF115 RNF122 RNF125 RNF126 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF168 RNF181 RNF185 RNF19B RNF2 RNF216 RNF220 RNF25 RNF26 RNF31 RNF38 RNF4 RNF41 RNF43 RNF5 RNF8 RNFT1 RPLP1 RSPRY1 SAT1 SH3RF1 SHOC2 SIAH1 SIAH2 SMURF1 SMURF2 SOX2 SQSTM1 ST7 STAM2 STAU1 STK25 STUB1 SYVN1 TMEM129 TOPORS TP53 TP73 TRAF6 TRAIP TRIM10 TRIM17 TRIM2 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM31 TRIM32 TRIM33 TRIM35 TRIM37 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM58 TRIM62 TRIM63 TRIM68 TRIM69 TRIM7 TRIM72 TRIM8 TUBA1A UBA1 UBA6 UBASH3B UBE2O UBE3A UBE3C UBE4A UBE4B UBOX5 UBR5 UBTD1 UFM1 UHRF1 USP7 UVSSA WBP2 WSB1 WWP1 WWP2 XIAP XPNPEP1 ZNRF1 ZNRF2 ZNRF4	35 interacting genes: ANKRD13B ASCC2 ATP5MF BRD7 C11orf58 C15orf39 CDIPT CDK2AP2 CLIC1 CSNK2A1 EEF1A1 GEMIN7 GSK3B LRIF1 MAP1LC3B MPC2 NSF NUDT21 NUDT3 PDCD4 PFDN1 PPP2CB PTN RCHY1 RPA2 RPLP2 RPS6KA6 SAT1 SGO1 SUOX TAB1 TPT1 TUBB2A UBE2D3 XRCC6
Entrez ID		7323	6176
HPRD ID		04269	01611
Ensembl ID		ENSG00000109332	ENSG00000137818
Uniprot IDs		A0A024RDH2 D6RAH7 P61077	A0A024R608 P05386
PDB IDs		1X23 2FUH 3L1Z 3RPG 3UGB 4BVU 4R8P 4S3O 5EGG 5IFR 6CP0 6T7F	2LBF 4BEH 4V6X
Enriched GO Terms of Interacting Partners?
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