C8B and C5

Data Source:
HPRD (in vitro)

		C8B	C5
Description		complement C8 beta chain	complement C5
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GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Membrane Extracellular Exosome Extracellular Vesicle	Extracellular Region Membrane Attack Complex Extracellular Space Extracellular Exosome
	Molecular Function	Protein-containing Complex Binding	Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity
	Biological Process	Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation	Activation Of MAPK Activity In Utero Embryonic Development Chemotaxis Inflammatory Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Endopeptidase Activity Cytolysis Regulation Of Complement Activation Positive Regulation Of Chemokine Production Positive Regulation Of Angiogenesis Cell Chemotaxis
Pathways		Terminal pathway of complement Regulation of Complement cascade	Terminal pathway of complement Activation of C3 and C5 Peptide ligand-binding receptors G alpha (i) signalling events Regulation of Complement cascade
Drugs		Zinc Copper Zinc acetate	Human immunoglobulin G Eculizumab Zinc Copper Ravulizumab Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Blood protein levels ( 29875488 28240269) Logical memory (delayed recall) in normal cognition ( 29274321)	Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Hip circumference adjusted for BMI ( 25673412) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 30891314 24390342 20453842 19503088)
Interacting Genes		3 interacting genes: C5 C8A CLU	22 interacting genes: ANKS6 AQP6 C2 C3 C5AR1 C6 C7 C8B CPB2 CPLX4 CPN1 CREB3L1 EBP KEL KIR3DL3 LMNA MMGT1 NEMP1 PGRMC2 POU6F2 SSMEM1 VEZT
Entrez ID		732	727
HPRD ID		00410	00405
Ensembl ID		ENSG00000021852	ENSG00000106804
Uniprot IDs		B7Z550 B7Z555 P07358	P01031 Q59GS8
PDB IDs		3OJY 6H03 6H04	1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S 4P39 4UU9 5B4P 5B71 5HCC 5HCD 5HCE 5I5K 6H03 6H04 6RPT
Enriched GO Terms of Interacting Partners?
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