C8A and C9

Data Source:
HPRD (in vitro)

		C8A	C9
Description		complement C8 alpha chain	complement C9
Image
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Extracellular Exosome Blood Microparticle	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Other Organism Cell Membrane Extracellular Exosome Blood Microparticle
	Molecular Function	Complement Binding Protein Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation	Cell Killing Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation Protein Homooligomerization
Pathways		Terminal pathway of complement Regulation of Complement cascade	Terminal pathway of complement Regulation of Complement cascade
Drugs		Zinc Zinc acetate	Copper
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Blood protein levels ( 28240269)	Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576 29875488) Chronic kidney disease ( 20383146) Health literacy ( 31250787) Systemic lupus erythematosus ( 19838195)
Interacting Genes		9 interacting genes: C8B C8G C9 CD59 GOLT1A GPR152 MMGT1 SLC10A1 SLC7A1	4 interacting genes: C8A CD59 CLU LAMTOR5
Entrez ID		731	735
HPRD ID		00409	00408
Ensembl ID		ENSG00000157131	ENSG00000113600
Uniprot IDs		P07357	P02748
PDB IDs		2QOS 2QQH 2RD7 3OJY 6H03 6H04	5FMW 6DLW 6H03 6H04
Enriched GO Terms of Interacting Partners?
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