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TYROBP and CD300E
Data Source:
HPRD
(in vitro)
TYROBP
CD300E
Description
transmembrane immune signaling adaptor TYROBP
CD300e molecule
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Integral Component Of Membrane
Secretory Granule Membrane
Plasma Membrane
Integral Component Of Membrane
Molecular Function
Signaling Receptor Binding
Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Transmembrane Signaling Receptor Activity
Protein Binding
Biological Process
Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway
Stimulatory C-type Lectin Receptor Signaling Pathway
Myeloid Leukocyte Activation
Microglial Cell Activation Involved In Immune Response
Neutrophil Activation Involved In Immune Response
Cellular Defense Response
Signal Transduction
Positive Regulation Of Gene Expression
Actin Cytoskeleton Organization
Osteoclast Differentiation
Negative Regulation Of B Cell Proliferation
Forebrain Development
Negative Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Natural Killer Cell Activation
Negative Regulation Of Transforming Growth Factor Beta1 Production
Positive Regulation Of Superoxide Anion Generation
Positive Regulation Of Macrophage Fusion
Intracellular Signal Transduction
Apoptotic Cell Clearance
Neutrophil Degranulation
Innate Immune Response
Response To Axon Injury
Regulation Of Immune Response
Protein Stabilization
Apoptotic Signaling Pathway
Positive Regulation Of Hippocampal Neuron Apoptotic Process
Negative Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Neuron Death
Positive Regulation Of Receptor Localization To Synapse
Positive Regulation Of Microglial Cell Mediated Cytotoxicity
Positive Regulation Of Protein Localization To Cell Surface
Positive Regulation Of Osteoclast Development
Innate Immune Response
Regulation Of Immune Response
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
DAP12 interactions
DAP12 interactions
DAP12 signaling
DAP12 signaling
Signal regulatory protein family interactions
Other semaphorin interactions
Neutrophil degranulation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
DAP12 interactions
Drugs
Diseases
Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); Nasu-Hakola disease
GWAS
Blood protein levels (
30072576
)
Dental caries (decayed and filled deciduous tooth surfaces) (
31533690
)
Interacting Genes
15 interacting genes:
CD300E
CLEC5A
KIR3DS1
KLRC3
KLRC4
KLRK1
NCR2
SIGLEC14
SIRPB1
SLC35B4
SYK
TMEM86A
TREM1
TREM2
ZAP70
4 interacting genes:
CTXN3
STX8
TRARG1
TYROBP
Entrez ID
7305
342510
HPRD ID
04996
17158
Ensembl ID
ENSG00000011600
ENSG00000186407
Uniprot IDs
O43914
X6RGC9
B4E0V9
Q496F6
PDB IDs
2L34
2L35
4WO1
4WOL
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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