TTK and RAD52

Data Source:
BioGRID (enzymatic study)

		TTK	RAD52
Description		TTK protein kinase	RAD52 homolog, DNA repair protein
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GO Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Spindle Membrane	Nucleus Nucleoplasm Protein-containing Complex Protein-DNA Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinetochore Binding	DNA Binding Single-stranded DNA Binding Protein Binding Identical Protein Binding
	Biological Process	Spindle Organization Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Positive Regulation Of Cell Population Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Female Meiosis Chromosome Segregation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Meiotic Spindle Assembly Checkpoint Protein Localization To Kinetochore Protein Autophosphorylation Chromosome Separation Protein Localization To Meiotic Spindle Midzone	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly Double-strand Break Repair DNA Recombination Mitotic Recombination Cellular Response To DNA Damage Stimulus DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Cellular Response To Oxidative Stress Double-strand Break Repair Via Single-strand Annealing Regulation Of Nucleotide-excision Repair
Pathways			SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA)
Drugs		Pyrazolanthrone Fostamatinib BOS172722
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Macular thickness ( 30535121)	Blood protein levels ( 29875488) Body mass index ( 26426971) Eosinophil percentage of granulocytes ( 27863252) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lung cancer ( 22899653) Neutrophil percentage of granulocytes ( 27863252) Small cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653 30578418) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		14 interacting genes: APP AZU1 CDCA8 CDK2 HSP90AA1 KNL1 MAPK6 POLR2A RAD52 RPS6KA1 TP53 TUBB TUBB1 USP16	25 interacting genes: ABL1 AURKB DCP1A ERCC1 ERCC2 ERCC3 ERCC4 KPNA3 KPNA5 MCM2 MCM3 MEOX1 MEOX2 NFYC PAX5 PLK3 RAD51 RDM1 RPA1 RPA2 SEM1 SUMO1 TTK UBE2I WRN
Entrez ID		7272	5893
HPRD ID		04973	11855
Ensembl ID		ENSG00000112742	ENSG00000002016
Uniprot IDs		P33981	B7Z2G8 B7Z5Q6 F5GX32 P43351 Q5DR82
PDB IDs		2X9E 2ZMC 2ZMD 3CEK 3DBQ 3GFW 3H9F 3HMN 3HMO 3HMP 3VQU 3W1F 3WYX 3WYY 3WZJ 3WZK 4B94 4BHZ 4BI0 4BI1 4BI2 4C4E 4C4F 4C4G 4C4H 4C4I 4C4J 4CV8 4CV9 4CVA 4D2S 4H7X 4H7Y 4JS8 4JT3 4O6L 4ZEG 5AP0 5AP1 5AP2 5AP3 5AP4 5AP5 5AP6 5AP7 5EH0 5EHL 5EHO 5EHY 5EI2 5EI6 5EI8 5LJJ 5MRB 5N7V 5N84 5N87 5N93 5N9S 5NA0 5NAD 5NTT 5O91 6B4W 6GVJ 6H3K 6N6O 6TN9 6TNB 6TNC 6TND	1H2I 1KN0 5JRB 5XRZ 5XS0
Enriched GO Terms of Interacting Partners?
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