TSN and PPP1R15A

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro, two hybrid)

		TSN	PPP1R15A
Description		translin	protein phosphatase 1 regulatory subunit 15A
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol	Protein Phosphatase Type 1 Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane
	Molecular Function	DNA Binding Single-stranded DNA Binding RNA Binding Endoribonuclease Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity Protein Kinase Binding Protein Phosphatase Activator Activity
	Biological Process	DNA Recombination Production Of SiRNA Involved In RNA Interference RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Positive Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Endoplasmic Reticulum Stress Negative Regulation Of Protein Dephosphorylation Regulation Of Translational Initiation By EIF2 Alpha Dephosphorylation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein Localization To Endoplasmic Reticulum Positive Regulation Of Peptidyl-serine Dephosphorylation Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Dephosphorylation
Pathways		Small interfering RNA (siRNA) biogenesis	Downregulation of TGF-beta receptor signaling Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Disease progression in age-related macular degeneration ( 29346644) Erectile dysfunction and prostate cancer treatment ( 20932654) Food antigen IgG levels ( 24962563) Hepcidin/ferritin ratio ( 27846281) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Smoking status (ever vs never smokers) ( 30643258)	High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		13 interacting genes: DVL3 GIT2 GORASP2 LNX1 MORF4L2 NTAQ1 PICK1 PPP1R15A SDCBP TSNAX UBE2I UBE2K ZBTB18	16 interacting genes: BAG1 BCAR1 CTBP2 EIF2S1 HABP4 HSPA1A KIF3A KMT2A LYN POU3F3 PPP1CA PPP1R1A RAD21 SMARCB1 TSN ZNF512B
Entrez ID		7247	23645
HPRD ID		08993	06572
Ensembl ID		ENSG00000211460	ENSG00000087074
Uniprot IDs		B3KRM8 Q15631	O75807
PDB IDs		1J1J 3PJA 3QB5 4WYV	4XPN
Enriched GO Terms of Interacting Partners?
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