PPP1R15A and KIF3A

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PPP1R15A	KIF3A
Description		protein phosphatase 1 regulatory subunit 15A	kinesin family member 3A
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane	Centrosome Centriole Cytosol Kinesin Complex Microtubule Spindle Microtubule Cilium Microtubule Cytoskeleton Kinesin II Complex Extracellular Exosome Ciliary Tip Axon Cytoplasm
	Molecular Function	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity Protein Kinase Binding Protein Phosphatase Activator Activity	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity Protein Phosphatase Binding Spectrin Binding Small GTPase Binding
	Biological Process	Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Positive Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Endoplasmic Reticulum Stress Negative Regulation Of Protein Dephosphorylation Regulation Of Translational Initiation By EIF2 Alpha Dephosphorylation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein Localization To Endoplasmic Reticulum Positive Regulation Of Peptidyl-serine Dephosphorylation Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Dephosphorylation	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Organelle Organization Microtubule-based Movement Anterograde Axonal Transport Centriole-centriole Cohesion Protein Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Microtubule Anchoring At Centrosome Intraciliary Transport Involved In Cilium Assembly Cilium Assembly Plus-end-directed Vesicle Transport Along Microtubule Protein Localization To Cell Junction
Pathways		Downregulation of TGF-beta receptor signaling Response of EIF2AK1 (HRI) to heme deficiency	Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Hedgehog 'off' state Intraflagellar transport Activation of SMO Activation of SMO COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31959851 31619474) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 25574825 22197932 26482879) Atopic march ( 26542096) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Refractive error ( 32231278)
Interacting Genes		16 interacting genes: BAG1 BCAR1 CTBP2 EIF2S1 HABP4 HSPA1A KIF3A KMT2A LYN POU3F3 PPP1CA PPP1R1A RAD21 SMARCB1 TSN ZNF512B	15 interacting genes: APP DISC1 GRB2 KIF3B KIF3C LIG4 MAP3K10 MAP3K11 NEK1 PLEKHA5 PPP1R15A RPGR TRIM14 TULP3 VHL
Entrez ID		23645	11127
HPRD ID		06572	05250
Ensembl ID		ENSG00000087074	ENSG00000131437
Uniprot IDs		O75807	B4DHG8 E9PES4 J3KPF9 Q05CT3 Q9Y496
PDB IDs		4XPN
Enriched GO Terms of Interacting Partners?
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