PIAS2 and NME7

Data Source:
BioGRID (two hybrid)

		PIAS2	NME7
Description		protein inhibitor of activated STAT 2	NME/NM23 family member 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm PML Body Nuclear Speck	Centrosome Cytosol
	Molecular Function	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding SUMO Ligase Activity	Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Negative Regulation Of Androgen Receptor Signaling Pathway	Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes
Drugs
Diseases
GWAS		Fruit consumption ( 32066663)	Coronary artery disease ( 29212778) D-dimer levels ( 21502573) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left-handedness ( 32989287) Pulse pressure ( 27841878 30578418) QT interval ( 30679814) Systolic blood pressure ( 27841878 30578418) Venous thromboembolism ( 21980494 22672568)
Interacting Genes		125 interacting genes: ACY3 ADA AKT1 AR ATF2 C1QA C5orf24 CBS CBSL CCHCR1 CCNDBP1 CDCA8 CGGBP1 CHMP4B CLDN2 CREB1 CREBBP CTBP1 DDX39B DES DEUP1 DMC1 DNMT3A EDC3 ELK1 ESR1 ESR2 EXOSC8 FAM118B FKBP6 FLI1 GFAP GLUL GOLGA2 GRHL2 GRM8 GTF2I GTF2IRD1 HDAC3 HMBOX1 HMG20A HMG20B HMGXB4 HNRNPCL1 HNRNPUL1 HOMER1 HOOK1 HUWE1 IKZF1 IMPDH1 JUN KIFC3 LCE1E LCE2C LMNA LMNB1 MAPK8 MAPKAPK2 MBD1 MITF MLX MSX2 MX1 MX2 NAV2 NME7 NR3C1 PAICS PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 PRKRA PRPH RFX2 RUFY1 RUNX1T1 SEC23A SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SOX5 SPATC1L SPINDOC SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 SYN3 TH TICAM2 TP53 TRAF2 TRAF3 TRAF5 TRIM23 TRIM27 TRIM50 TRIM55 TRIM63 TSR2 TXLNA UBASH3B UBE2I UBE2L3 UBQLN1 ZBED1 ZBTB16 ZBTB8A ZC3H10 ZFP42 ZNF319 ZNF451 ZNRD2	75 interacting genes: AMOTL2 ARHGAP9 BTBD6 C1orf189 CARD10 CBY2 CCDC136 CCDC33 CCDC88B CCHCR1 CDC42EP2 CEP72 DDIT4L DDX1 DISC1 DNAI7 EFHC2 FKBP6 FLOT1 FOSL1 FOSL2 GATAD2B GLIS2 GOLGA2 GSC2 HAUS8 IKZF1 IKZF3 INCA1 ISY1-RAB43 KRT18 KRT75 LNX1 MAP4K4 MED11 MED30 MEI4 MEOX2 MYOT NAB2 NEFL NFKBIL1 NIF3L1 NME4 NT5C2 OFD1 PAX4 PIAS2 PICK1 POU6F2 PROSER3 PSMA1 REL RUBCN SHTN1 SNAPIN SNX32 SYCE1 TCF4 TCHP TEKT1 TEPSIN THAP10 TNIP1 TNNI2 TRIM27 TRIM48 TUFT1 YWHAQ ZBTB48 ZNF23 ZNF263 ZNF343 ZNF526 ZNF620
Entrez ID		9063	29922
HPRD ID		06944	11394
Ensembl ID		ENSG00000078043	ENSG00000143156
Uniprot IDs		A0A024RC49 O75928 Q2TA77	A0A024R8Z7 Q9Y5B8
PDB IDs		2ASQ 4FO9
Enriched GO Terms of Interacting Partners?
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