ACTG1 and RPS6KA5

Data Source:
BioGRID (two hybrid)

		ACTG1	RPS6KA5
Description		actin gamma 1	ribosomal protein S6 kinase A5
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GO Annotations	Cellular Component	Extracellular Space Nucleus Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Apical Junction Complex Extracellular Exosome Blood Microparticle Dense Body	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Profilin Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Angiogenesis Morphogenesis Of A Polarized Epithelium Retina Homeostasis Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Cell Junction Assembly Maintenance Of Blood-brain Barrier Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Ephrin Receptor Signaling Pathway Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Membrane Organization Platelet Aggregation Positive Regulation Of Wound Healing Postsynaptic Actin Cytoskeleton Organization Tight Junction Assembly Regulation Of Transepithelial Transport Protein Localization To Bicellular Tight Junction	Negative Regulation Of Cytokine Production Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Histone Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Histone Phosphorylation Positive Regulation Of Histone Acetylation Intracellular Signal Transduction Histone H3-S10 Phosphorylation Histone H3-S28 Phosphorylation Histone H2A-S1 Phosphorylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	ERK/MAPK targets CREB phosphorylation NCAM signaling for neurite out-growth Recycling pathway of L1 CD209 (DC-SIGN) signaling
Drugs		Copper Artenimol
Diseases
GWAS		Hand grip strength ( 29313844) Refractive error ( 32231278)	Adult body size ( 32376654) Bitter alcoholic beverage consumption ( 31046077) Femoral neck bone mineral density ( 29499414 22504420) Fractures ( 30158200) Heel bone mineral density ( 30598549) Lumbar spine bone mineral density ( 29499414) Multiple sclerosis ( 31604244) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		68 interacting genes: ABLIM1 ACTB ANXA5 ATF7IP BCAP31 BIN1 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDC37 CDKN2A CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DUX4 DYNLL1 EHHADH EIF6 FHOD1 FPR1 GIT2 GSN GZMA GZMK HRAS HSPB2 LGALS13 LIG4 LINC01554 LSP1 MAP1A MAPK6 MAPT MCPH1 MYO1A MYOC NDRG1 NR3C2 NTAQ1 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 SRPK2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WIPF1	60 interacting genes: ACTG1 AKT1S1 ALG8 APP ATF1 ATF2 BAD CEBPB CREB1 CREBBP CRMP1 CSNK2B CTNNA3 DDAH2 DNAJC11 EIF4EBP1 EP300 ERH ETV1 EZH2 FN1 GPRASP2 H1-1 H1-5 H2AW H2BC21 H2BC3 H2BU1 H3-4 H3C14 H3C6 H4-16 H4C14 HMGN1 HSPB2 IL17RB ITSN1 MAP3K20 MAPK11 MAPK14 MAPT MBP MDFIC NR4A1 PDLIM1 PLA2G4A RAI1 RELA RNF19A ROBO2 RPA1 SMAD6 SMARCB1 STAT1 STAT3 STK11 TH TXNDC11 UNC119 ZNF775
Entrez ID		71	9252
HPRD ID		00017	06789
Ensembl ID		ENSG00000184009	ENSG00000100784
Uniprot IDs		P63261	O75582
PDB IDs		5JLH 6CXI 6CXJ 6G2T 6V62 6V63 6WK1 6WK2	1VZO 3KN5 3KN6
Enriched GO Terms of Interacting Partners?
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