ACTG1 and PPP1R9A

Data Source:
HPRD (in vitro, in vivo)

		ACTG1	PPP1R9A
Description		actin gamma 1	protein phosphatase 1 regulatory subunit 9A
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Apical Junction Complex Extracellular Exosome Blood Microparticle Dense Body	Cytoplasm Cytosol Postsynaptic Density Actin Cytoskeleton Filopodium Dendrite Cortical Actin Cytoskeleton Neuromuscular Junction Neuronal Cell Body Dendritic Spine Neck Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Growth Cone Lamellipodium
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Profilin Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton	Protein Binding Protein C-terminus Binding Protein Phosphatase 1 Binding Protein Kinase Binding Protein Domain Specific Binding Identical Protein Binding Ion Channel Binding Actin Filament Binding GTPase Binding
	Biological Process	Angiogenesis Morphogenesis Of A Polarized Epithelium Retina Homeostasis Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Cell Junction Assembly Maintenance Of Blood-brain Barrier Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Ephrin Receptor Signaling Pathway Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Membrane Organization Platelet Aggregation Positive Regulation Of Wound Healing Postsynaptic Actin Cytoskeleton Organization Tight Junction Assembly Regulation Of Transepithelial Transport Protein Localization To Bicellular Tight Junction	Actin Filament Organization Aging Positive Regulation Of Neuron Projection Development Calcium-mediated Signaling Regulation Of Actin Filament Polymerization Neuron Projection Development Positive Regulation Of Protein Kinase Activity Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly Regulation Of Synapse Structural Plasticity Regulation Of Synapse Assembly Excitatory Postsynaptic Potential Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Cellular Response To Toxic Substance Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Depression Negative Regulation Of Spontaneous Neurotransmitter Secretion
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		Copper Artenimol
Diseases
GWAS		Hand grip strength ( 29313844) Refractive error ( 32231278)	Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Waist circumference ( 28552196)
Interacting Genes		68 interacting genes: ABLIM1 ACTB ANXA5 ATF7IP BCAP31 BIN1 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDC37 CDKN2A CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DUX4 DYNLL1 EHHADH EIF6 FHOD1 FPR1 GIT2 GSN GZMA GZMK HRAS HSPB2 LGALS13 LIG4 LINC01554 LSP1 MAP1A MAPK6 MAPT MCPH1 MYO1A MYOC NDRG1 NR3C2 NTAQ1 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 SRPK2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WIPF1	10 interacting genes: ACTG1 PPP1CA PPP1CB PPP1CC PPP1R2 PPP1R9B PRKAR1B RPS6KA1 RPS6KB1 TGOLN2
Entrez ID		71	55607
HPRD ID		00017	16000
Ensembl ID		ENSG00000184009	ENSG00000158528
Uniprot IDs		P63261	A4D1I0 B7ZLX4 Q9ULJ8
PDB IDs		5JLH 6CXI 6CXJ 6G2T 6V62 6V63 6WK1 6WK2	1WF8
Enriched GO Terms of Interacting Partners?
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