TIMP1 and ECH1

Data Source:
HPRD (two hybrid)

		TIMP1	ECH1
Description		TIMP metallopeptidase inhibitor 1	enoyl-CoA hydratase 1
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GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome	Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Membrane Extracellular Exosome
	Molecular Function	Protease Binding Cytokine Activity Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Zinc Ion Binding Peptidase Inhibitor Activity	Protein Binding Delta3,5-delta2,4-dienoyl-CoA Isomerase Activity
	Biological Process	Cell Activation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Platelet Degranulation Aging Positive Regulation Of Cell Population Proliferation Response To Hormone Response To Organic Substance Negative Regulation Of Endopeptidase Activity Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Response To Cytokine Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Response To Peptide Hormone Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Membrane Protein Ectodomain Proteolysis Cartilage Development Cellular Response To UV-A Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Metallopeptidase Activity Regulation Of Integrin-mediated Signaling Pathway	Protein Targeting To Peroxisome Fatty Acid Beta-oxidation
Pathways		Platelet degranulation Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation	Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Logical memory (immediate recall) in mild cognitive impairment ( 29274321)
Interacting Genes		8 interacting genes: CD63 ECH1 EEF1B2 MMP1 MMP2 MMP3 MYOC RECQL5	11 interacting genes: APP CSTF2 EEF1D EEF1G FAM9B HTT PAFAH1B3 SERPINB9 STAT3 TIMP1 TLR10
Entrez ID		7076	1891
HPRD ID		02371	02825
Ensembl ID		ENSG00000102265	ENSG00000104823
Uniprot IDs		B4DJK3 P01033 Q6FGX5	A0A384MR44 Q13011
PDB IDs		1D2B 1LQN 1OO9 1UEA 2J0T 3MA2 3V96 6MAV 6N9D	2VRE
Enriched GO Terms of Interacting Partners?
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