TFF1 and XRCC3

Data Source:
BioGRID (two hybrid)

		TFF1	XRCC3
Description		trefoil factor 1	X-ray repair cross complementing 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Mitochondrion Cytosol Rad51C-XRCC3 Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Growth Factor Activity	Four-way Junction DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Crossover Junction Endodeoxyribonuclease Activity
	Biological Process	Carbohydrate Metabolic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Iron Ion Cell Differentiation Maintenance Of Gastrointestinal Epithelium Response To Immobilization Stress Response To Peptide Hormone	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus Response To Organic Substance Regulation Of Centrosome Duplication Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Resolution Of Mitotic Recombination Intermediates Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint T-circle Formation Telomeric Loop Disassembly Telomere Maintenance Via Telomere Trimming
Pathways		Estrogen-dependent gene expression	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange
Drugs		Raloxifene Afimoxifene
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Pancreatic cancer ( 22158540)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 26426971 29273807) Schizophrenia ( 25056061 29483656)
Interacting Genes		20 interacting genes: AKT1 APC ATM BTN3A1 BTNL8 CD300LD ESR2 FCRL4 FGFR2 GKN2 MUC6 RAD51 SGTB SIGLEC8 TSG101 UBQLN1 UBQLN4 VSNL1 XRCC3 ZNF250	22 interacting genes: BAP1 BCAS3 CXCL1 FANCG GREB1 ITIH5 LRATD2 MRC2 OSGIN1 PALB2 PSMC3IP RAD51 RAD51C RAD51D RNF20 SCGB3A1 SERPINB5 SNAI1 SWSAP1 TFF1 ZNHIT3 ZSWIM7
Entrez ID		7031	7517
HPRD ID		00219	07201
Ensembl ID		ENSG00000160182	ENSG00000126215
Uniprot IDs		P04155	O43542 Q53XC8
PDB IDs		1HI7 1PS2 6V1D
Enriched GO Terms of Interacting Partners?
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