TF and IGFBP3

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		TF	IGFBP3
Description		transferrin	insulin like growth factor binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Late Endosome Endoplasmic Reticulum Lumen Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Cell Surface Endosome Membrane Apical Plasma Membrane Endocytic Vesicle Clathrin-coated Vesicle Membrane Extrinsic Component Of External Side Of Plasma Membrane Cytoplasmic Vesicle Vesicle Secretory Granule Lumen Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Blood Microparticle HFE-transferrin Receptor Complex	Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex
	Molecular Function	Protein Binding Ferrous Iron Binding Ferric Iron Binding Iron Chaperone Activity Transferrin Receptor Binding	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Metal Ion Binding
	Biological Process	Retina Homeostasis Platelet Degranulation Iron Ion Transport Cellular Iron Ion Homeostasis Actin Filament Organization Activation Of JUN Kinase Activity Antibacterial Humoral Response Osteoclast Differentiation Regulation Of Protein Stability Transferrin Transport Regulation Of Iron Ion Transport Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Receptor-mediated Endocytosis Iron Ion Homeostasis SMAD Protein Signal Transduction Membrane Organization ERK1 And ERK2 Cascade Cellular Response To Iron Ion Positive Regulation Of Cell Motility	Regulation Of Cell Growth Osteoblast Differentiation Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphoprotein Phosphatase Activity Post-translational Protein Modification Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Post-translational protein phosphorylation Iron uptake and transport Transferrin endocytosis and recycling	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) TP53 Regulates Transcription of Death Receptors and Ligands Post-translational protein phosphorylation
Drugs		Cisplatin Isoflurophate Aluminium Iron Zinc Manganese Copper Dichlorvos Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form	Alitretinoin Mecasermin
Diseases
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) HDL cholesterol levels ( 32203549) Hepcidin levels ( 21785125) Hereditary hemochromatosis-related traits (HFE mutation homozygotes) ( 25457201) Iron status biomarkers ( 25224454 21483845 21208937 19084217) Iron status biomarkers (iron levels) ( 28334935 25352340) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 28334935 25352340) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252)	Birth weight ( 31043758) Blood pressure traits (multi-trait analysis) ( 28498854) Blood protein levels ( 30072576 29875488 23696881) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 27841878 28498854 30578418) FEV1 ( 30804560) Height ( 25282103 31562340) Hypospadias ( 25108383) Insulin-like growth factors ( 21216879) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Male-pattern baldness ( 27182965) Molybdenum levels ( 26025379) Night sleep phenotypes ( 27126917) Offspring birth weight ( 31043758) Poor prognosis in Crohn's disease ( 28067912) Pulse pressure ( 26390057 28135244 27841878 29403010 28739976 27618448 28498854 30487518) QRS duration ( 27577874 21076409) Rosacea symptom severity ( 29771307) Sitting height ratio ( 25865494) Subjective response to lithium treatment in bipolar disorder ( 26503763) Systolic blood pressure ( 27841878 27618447 27618448) Tonsillectomy ( 27182965 28928442) Venous thromboembolism ( 26888256)
Interacting Genes		41 interacting genes: AQP9 CALR CANX CLDN5 CPLX4 CUBN DRD2 ELOVL4 ERGIC3 FAM210B GJB1 GOLM1 GPR42 GPX8 GRB2 HSD17B13 IGF1 IGF2 IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 LAMC3 LEUTX PGRMC2 RMDN3 SH3BP2 SLC10A6 SLC26A6 SMAD3 SORT1 SPINT1 SYT2 TFR2 TFRC TIMELESS TMEM52B TUBB3 VKORC1	38 interacting genes: ADAM12 AURKA BMPR1A BUB1 CAV1 CCND1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FBXW7 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 KRAS LTBP1 MLH3 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 PPARG RAD54B RXRA STK11 TF
Entrez ID		7018	3486
HPRD ID		01811	00899
Ensembl ID		ENSG00000091513	ENSG00000146674
Uniprot IDs		A0PJA6 P02787 Q06AH7	B3KPF0 P17936
PDB IDs		1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 1SUV 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L 3S9M 3S9N 3SKP 3V83 3V89 3V8X 3VE1 4H0W 4X1B 4X1D 5DYH 5H52 5WTD 5X5P 5Y6K 6CTC 6D03 6D04 6D05 6JAS 6SOY 6SOZ 6UJ6
Enriched GO Terms of Interacting Partners?
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