TF and SLC10A6

Data Source:
BioGRID (two hybrid)

		TF	SLC10A6
Description		transferrin	solute carrier family 10 member 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Late Endosome Endoplasmic Reticulum Lumen Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Cell Surface Endosome Membrane Apical Plasma Membrane Endocytic Vesicle Clathrin-coated Vesicle Membrane Extrinsic Component Of External Side Of Plasma Membrane Cytoplasmic Vesicle Vesicle Secretory Granule Lumen Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Blood Microparticle HFE-transferrin Receptor Complex	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Ferrous Iron Binding Ferric Iron Binding Iron Chaperone Activity Transferrin Receptor Binding	Protein Binding Bile Acid:sodium Symporter Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity
	Biological Process	Retina Homeostasis Platelet Degranulation Iron Ion Transport Cellular Iron Ion Homeostasis Actin Filament Organization Activation Of JUN Kinase Activity Antibacterial Humoral Response Osteoclast Differentiation Regulation Of Protein Stability Transferrin Transport Regulation Of Iron Ion Transport Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Receptor-mediated Endocytosis Iron Ion Homeostasis SMAD Protein Signal Transduction Membrane Organization ERK1 And ERK2 Cascade Cellular Response To Iron Ion Positive Regulation Of Cell Motility	Sodium Ion Transport Bile Acid And Bile Salt Transport Sodium-dependent Organic Anion Transport Transmembrane Transport
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Post-translational protein phosphorylation Iron uptake and transport Transferrin endocytosis and recycling	Transport of bile salts and organic acids, metal ions and amine compounds
Drugs		Cisplatin Isoflurophate Aluminium Iron Zinc Manganese Copper Dichlorvos Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) HDL cholesterol levels ( 32203549) Hepcidin levels ( 21785125) Hereditary hemochromatosis-related traits (HFE mutation homozygotes) ( 25457201) Iron status biomarkers ( 25224454 21483845 21208937 19084217) Iron status biomarkers (iron levels) ( 28334935 25352340) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 28334935 25352340) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252)	Eyebrow thickness ( 26926045) Insulin-related traits ( 22791750) Refractive error ( 32231278)
Interacting Genes		41 interacting genes: AQP9 CALR CANX CLDN5 CPLX4 CUBN DRD2 ELOVL4 ERGIC3 FAM210B GJB1 GOLM1 GPR42 GPX8 GRB2 HSD17B13 IGF1 IGF2 IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 LAMC3 LEUTX PGRMC2 RMDN3 SH3BP2 SLC10A6 SLC26A6 SMAD3 SORT1 SPINT1 SYT2 TFR2 TFRC TIMELESS TMEM52B TUBB3 VKORC1	146 interacting genes: ACSL5 ANKRD46 APOD ARL6IP1 ARV1 ATP13A1 BMP10 BTN2A2 C11orf24 C2CD2L CCDC167 CCL4 CDIPT CDS1 CLDND2 CMTM5 CNIH1 COL4A5 COMT COX20 CYB5B CYB5R3 CYP4F2 DERL1 DGAT2L6 EMC6 ERG28 FA2H FAM3C FAXDC2 FIS1 FKBP8 FMO1 FUNDC2 FXYD3 FXYD6 FXYD6-FXYD2 GIMAP1 GJB6 GLB1 GOLT1B GOSR2 GPR151 GYPA GYPC HTATIP2 IGFBP5 ITGAM LPAR3 LSS MALL MFSD5 MFSD6 MGLL MS4A1 NAT8 NEU1 NINJ2 NRM OR7D4 ORMDL1 OSMR PEDS1-UBE2V1 PEX16 PIP4P1 PIP4P2 PLLP PLP1 PNLIPRP1 PRAF2 PRRT2 PSEN1 PSENEN RNF24 RTP2 RUSF1 SACM1L SCAMP4 SCAMP5 SCD SERP1 SERP2 SFT2D2 SFXN1 SLC12A7 SLC25A46 SLC29A2 SLC30A2 SLC30A3 SLC35C2 SLC35G2 SLC38A1 SLC39A6 SLC39A9 SLC41A1 SLC66A2 SLC7A1 SMAGP SMIM1 SNORC STATH STX12 STX7 STX8 SYNGR1 SYNJ2BP TAP1 TECR TF TM4SF4 TMEM107 TMEM11 TMEM119 TMEM120B TMEM128 TMEM143 TMEM14A TMEM14C TMEM203 TMEM208 TMEM218 TMEM229B TMEM234 TMEM239 TMEM242 TMEM252 TMEM262 TMEM50B TMEM60 TMEM65 TMEM86A TMEM86B TPRG1 TREX1 TSNARE1 TSPAN2 TSPO2 TVP23B UBE2J1 UNC50 VAMP4 YIPF1 YIPF2 YIPF6 ZDHHC15 ZFPL1
Entrez ID		7018	345274
HPRD ID		01811	11593
Ensembl ID		ENSG00000091513	ENSG00000145283
Uniprot IDs		A0PJA6 P02787 Q06AH7	Q3KNW5
PDB IDs		1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 1SUV 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L 3S9M 3S9N 3SKP 3V83 3V89 3V8X 3VE1 4H0W 4X1B 4X1D 5DYH 5H52 5WTD 5X5P 5Y6K 6CTC 6D03 6D04 6D05 6JAS 6SOY 6SOZ 6UJ6
Enriched GO Terms of Interacting Partners?
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