TBX5 and BAIAP2

Data Source:
BioGRID (two hybrid)

		TBX5	BAIAP2
Description		T-box transcription factor 5	BAR/IMD domain containing adaptor protein 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex Protein-DNA Complex	Ruffle Nucleoplasm Cytoplasm Cytosol Plasma Membrane Adherens Junction Actin Cytoskeleton Filopodium Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding	Protein Binding Protein C-terminus Binding Cytoskeletal Anchor Activity Identical Protein Binding Proline-rich Region Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Cell Fate Specification Morphogenesis Of An Epithelium Bundle Of His Development Atrioventricular Valve Morphogenesis Endocardial Cushion Development Cardiac Left Ventricle Formation Ventricular Septum Development Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cell-cell Signaling Pattern Specification Process Heart Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Lung Development Embryonic Limb Morphogenesis Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Forelimb Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Pericardium Development Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Atrial Septum Morphogenesis Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation	Plasma Membrane Organization Axonogenesis Insulin Receptor Signaling Pathway Regulation Of Cell Shape Response To Bacterium Positive Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Actin Filament Bundle Assembly Actin Crosslink Formation Cell-cell Adhesion Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases		Holt-Oram syndrome
GWAS		Airflow obstruction ( 22837378) Atrial fibrillation ( 28416818 28416822 30061737 29892015) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood pressure ( 21909110) Bone mineral density (total hip) ( 29883787) Diastolic blood pressure ( 28135244 19430479 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732 20062063) FEV1 ( 30804560) Hypertension ( 30487518) Laryngeal squamous cell carcinoma ( 25194280) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Mean arterial pressure ( 30487518) Obesity-related traits ( 23251661) P wave duration ( 28794112) Peak expiratory flow ( 30804560) Pelvic organ prolapse ( 32184442) Percent mammographic density ( 22532574) PR interval ( 30046033 32439900 20062060 25035420 23139255 21347284) Prostate cancer ( 23535732 25939597) QRS duration ( 27577874 30012220 21076409) Receptive language ability ( 32635940) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355) Visceral fat ( 22589738)	Adult body size ( 32376654) Adverse response to drug ( 30420678) Beef consumption ( 32066663) Body size at age 10 ( 32376654) Breast cancer ( 29871690) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Feeling tense ( 29500382) General factor of neuroticism ( 30867560) Memory performance ( 24392092) Neurociticism ( 29500382) Neuroticism ( 29255261) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		7 interacting genes: BAIAP2 FBXO25 GATA4 KAT5 KDM6A NKX2-5 ZMYND10	39 interacting genes: ADGRB1 APP ATN1 BAIAP2L1 C19orf25 CDC42 COG6 DAPK1 DIAPH1 EGFR ENAH EPS8 ERG28 ESPN GRB10 HOXD8 KANK1 KDM1A LIN7A LIN7B LIN7C MARK2 NCKIPSD NEDD4 PAK1 PBX2 PRR13 RAC1 RTN4 SF3A2 SF3B4 SHANK1 SHANK2 SRPK2 TBX5 TP53BP2 WASF1 WASF2 YWHAG
Entrez ID		6910	10458
HPRD ID		03372	05686
Ensembl ID		ENSG00000089225	ENSG00000175866
Uniprot IDs		Q99593	I3L4C2 Q9UQB8
PDB IDs		2X6U 2X6V 4S0H 5BQD	1WDZ 1Y2O 2YKT 3RNJ 4JS0 6BCR 6BCY 6BD1 6BD2 6BQT 6ZEG 6ZEI
Enriched GO Terms of Interacting Partners?
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