TACR1 and TAC4

Data Source:
HPRD (in vivo, in vitro)

		TACR1	TAC4
Description		tachykinin receptor 1	tachykinin precursor 4
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Sperm Flagellum Sperm Head Sperm Midpiece	Extracellular Space
	Molecular Function	Tachykinin Receptor Activity Protein Binding Substance P Receptor Activity	Substance P Receptor Binding
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Detection Of Abiotic Stimulus Response To Pain Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility	Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Regulation Of Blood Pressure Positive Regulation Of Flagellated Sperm Motility
Pathways		Tachykinin receptors bind tachykinins G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Tramadol Aprepitant Ketamine Vapreotide AV608 GW 597599 CP-122721 R673 SR 140333 Casopitant Netupitant Rolapitant Vestipitant Vofopitant Fosnetupitant
Diseases
GWAS		Brain connectivity ( 23471985) Chronotype ( 30696823) Diisocyanate-induced asthma ( 25918132) Gout ( 32238385) Nonunion in individuals with fractures ( 30680360) Pursuit maintenance gain ( 29064472) Seborrheic dermatitis ( 29203360) Sexual dimorphism in anthropometric traits ( 23754948) Weight ( 28552196)
Interacting Genes		7 interacting genes: CCDC167 GPRASP1 GRK5 TAC1 TAC3 TAC4 TMEM147	3 interacting genes: TACR1 TACR2 TACR3
Entrez ID		6869	255061
HPRD ID		01208	09701
Ensembl ID		ENSG00000115353	ENSG00000176358
Uniprot IDs		P25103	Q86UU9
PDB IDs		2KS9 2KSA 2KSB 6E59 6HLL 6HLO 6HLP	2MOC
Enriched GO Terms of Interacting Partners?
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