TAC4 and TACR1

Data Source:
HPRD (in vivo, in vitro)

		TAC4	TACR1
Description		tachykinin precursor 4	tachykinin receptor 1
Image
GO Annotations	Cellular Component	Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane Sperm Flagellum Sperm Head Sperm Midpiece
	Molecular Function	Substance P Receptor Binding	Tachykinin Receptor Activity Protein Binding Substance P Receptor Activity
	Biological Process	Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Regulation Of Blood Pressure Positive Regulation Of Flagellated Sperm Motility	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Detection Of Abiotic Stimulus Response To Pain Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility
Pathways			Tachykinin receptors bind tachykinins G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Tramadol Aprepitant Ketamine Vapreotide AV608 GW 597599 CP-122721 R673 SR 140333 Casopitant Netupitant Rolapitant Vestipitant Vofopitant Fosnetupitant
Diseases
GWAS			Brain connectivity ( 23471985) Chronotype ( 30696823) Diisocyanate-induced asthma ( 25918132) Gout ( 32238385) Nonunion in individuals with fractures ( 30680360) Pursuit maintenance gain ( 29064472) Seborrheic dermatitis ( 29203360) Sexual dimorphism in anthropometric traits ( 23754948) Weight ( 28552196)
Interacting Genes		3 interacting genes: TACR1 TACR2 TACR3	7 interacting genes: CCDC167 GPRASP1 GRK5 TAC1 TAC3 TAC4 TMEM147
Entrez ID		255061	6869
HPRD ID		09701	01208
Ensembl ID		ENSG00000176358	ENSG00000115353
Uniprot IDs		Q86UU9	P25103
PDB IDs		2MOC	2KS9 2KSA 2KSB 6E59 6HLL 6HLO 6HLP
Enriched GO Terms of Interacting Partners?
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