TAC1 and TACR1

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo)

		TAC1	TACR1
Description		tachykinin precursor 1	tachykinin receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Axon Neuronal Cell Body Synapse	Plasma Membrane Integral Component Of Plasma Membrane Sperm Flagellum Sperm Head Sperm Midpiece
	Molecular Function	Substance P Receptor Binding	Tachykinin Receptor Activity Protein Binding Substance P Receptor Activity
	Biological Process	Positive Regulation Of Acute Inflammatory Response Inflammatory Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Insemination Long-term Memory Regulation Of Blood Pressure Associative Learning Detection Of Abiotic Stimulus Response To Hormone Negative Regulation Of Heart Rate Positive Regulation Of Epithelial Cell Migration Sensory Perception Of Pain Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Positive Regulation Of Renal Sodium Excretion Response To Morphine Positive Regulation Of Action Potential Positive Regulation Of Ossification Positive Regulation Of Saliva Secretion Response To Pain Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Stress Fiber Assembly Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Corticosterone Secretion	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Detection Of Abiotic Stimulus Response To Pain Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility
Pathways		Tachykinin receptors bind tachykinins G alpha (q) signalling events	Tachykinin receptors bind tachykinins G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Tramadol Aprepitant Ketamine Vapreotide AV608 GW 597599 CP-122721 R673 SR 140333 Casopitant Netupitant Rolapitant Vestipitant Vofopitant Fosnetupitant
Diseases
GWAS		Adventurousness ( 30643258) Adverse response to radiation therapy ( 23719583) Blood protein levels ( 30072576) Feeling nervous ( 29500382) General risk tolerance (MTAG) ( 30643258) Regular attendance at a religious group ( 29970889) Response to platinum-based agents ( 22020760) Squamous cell lung carcinoma ( 28604730)	Brain connectivity ( 23471985) Chronotype ( 30696823) Diisocyanate-induced asthma ( 25918132) Gout ( 32238385) Nonunion in individuals with fractures ( 30680360) Pursuit maintenance gain ( 29064472) Seborrheic dermatitis ( 29203360) Sexual dimorphism in anthropometric traits ( 23754948) Weight ( 28552196)
Interacting Genes		10 interacting genes: ARHGEF40 BAG6 CENPB FN1 MEP1A PREP TACR1 TACR2 TACR3 XRCC6	7 interacting genes: CCDC167 GPRASP1 GRK5 TAC1 TAC3 TAC4 TMEM147
Entrez ID		6863	6869
HPRD ID		08876	01208
Ensembl ID		ENSG00000006128	ENSG00000115353
Uniprot IDs		P20366 Q9Y494	P25103
PDB IDs		2B19 2KS9 2KSA 2KSB 4HOM	2KS9 2KSA 2KSB 6E59 6HLL 6HLO 6HLP
Enriched GO Terms of Interacting Partners?
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