STAT3 and TSHR

Data Source:
HPRD (in vitro, in vivo)

		STAT3	TSHR
Description		signal transducer and activator of transcription 3	thyroid stimulating hormone receptor
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane RNA Polymerase II Transcription Regulator Complex	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Receptor Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Repressing Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Protein Phosphatase Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity Primary MiRNA Binding	Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Temperature Homeostasis Eye Photoreceptor Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Defense Response Inflammatory Response Signal Transduction Receptor Signaling Pathway Via JAK-STAT Nervous System Development Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Viral Process Phosphorylation Cytokine-mediated Signaling Pathway Sexual Reproduction Positive Regulation Of Cell Migration Intracellular Receptor Signaling Pathway Response To Estradiol Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Hormone Stimulus Leptin-mediated Signaling Pathway Somatic Stem Cell Population Maintenance Interleukin-15-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Interleukin-21-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Glucose Homeostasis Eating Behavior Response To Peptide Hormone Cellular Response To Leptin Stimulus Response To Leptin Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cell Cycle Radial Glial Cell Differentiation Regulation Of Feeding Behavior Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Cellular Response To Cytokine Stimulus T-helper 17 Type Immune Response T-helper 17 Cell Lineage Commitment Energy Homeostasis Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of MiRNA Mediated Inhibition Of Translation Negative Regulation Of Primary MiRNA Processing Positive Regulation Of Gene Silencing By MiRNA	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone
Pathways		Interleukin-6 signaling BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signalling to STAT3 Senescence-Associated Secretory Phenotype (SASP) Signaling by Leptin POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Association of TriC/CCT with target proteins during biosynthesis Transcriptional regulation of pluripotent stem cells Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling PTK6 Activates STAT3 PTK6 Activates STAT3 Interleukin-20 family signaling MET activates STAT3 MET activates STAT3 Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-37 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-21 signaling Transcriptional regulation of granulopoiesis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Growth hormone receptor signaling	Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		ENMD-1198	Thyrotropin alfa
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) Oral cancer	Congenital nongoitrous hypothyroidism (CHNG)
GWAS		Apolipoprotein B levels ( 32203549) Atopic dermatitis ( 26482879) Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Crohn's disease ( 18587394 28067908 21102463 23266558) Crohn's disease or systemic sclerosis ( 32024964) Diastolic blood pressure ( 30578418) Inflammatory bowel disease ( 27569725 28067908 26278503 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244 22190364 24076602 21833088 20159113) Psoriasis ( 25903422 23143594) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458) Ulcerative colitis ( 28067908)	Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)
Interacting Genes		208 interacting genes: ABL2 ADRB2 AMBP AR ARFIP2 ASXL1 ATF3 BATF3 BCKDK BHLHE40 BICD1 BLK BMX BRCA1 BRWD1 CA8 CAPN1 CAPNS1 CBL CCDC87 CCND1 CCR1 CCR5 CDK9 CDKN1A CEP120 CHTF18 CNDP2 CORO1A CREBBP CSF2RB CSF3R CXCR4 DAXX DOK2 DOK3 DTNA ECH1 EGFR EIF2AK2 ELP2 EP300 EPHA3 ERBB2 ERBIN ESR1 FAM117B FBXW7 FER FES FGFR3 FGFR4 FGR FHL2 FLT1 FOXM1 FYN GATA1 GATA2 GHR GNL3 GSTCD GTF2I HCK HDAC1 HDAC2 HDAC3 HES1 HES5 HESX1 HIF1A HIVEP1 HLA-A HNF1A HNRNPM HOXC11 HSP90AA1 HSP90AB1 IFNAR1 IFNAR2 IGF1R IL1RAP IL22RA1 IL23R IL2RA IL2RB IL6R IL6ST IL7R IMPDH2 IRAK1 JAK1 JAK2 JAK3 JUN KAT5 KDM1A KHDRBS1 KLF15 KPNA1 KPNA6 KRTAP10-7 LAMB2 LASP1 LCK LEPR LMO2 LYN MAP3K13 MAP3K7 MAPK1 MAPK3 MAPK8 MAPKAPK2 MEG3 MET MNDA MORC4 MPZL1 MRPS31 MTOR MYOD1 NACAD NCOA1 NDUFA13 NFKB1 NFKBIZ NIF3L1 NLK NMI NR3C1 NR4A1 NUFIP2 NXT2 OFCC1 OGDHL PAFAH1B2 PAQR7 PCBD2 PDGFRA PDGFRB PDIA3 PELP1 PIAS3 PIK3R1 PIK3R2 PIK3R3 PINK1 PML POM121 PPARD PRKCD PTK2B PTMA PTPN1 PTPN11 PTPN2 RABGAP1 RAC1 RACK1 RB1 RELA RET RPA2 RPL11 RPS6KA5 RPS9 RRAD SCAF11 SETD7 SH2D2A SH3BP2 SIAH2 SIN3A SMARCA4 SPRY1 SRC SRI SRRT SS18L1 STAP2 STAT1 STAT4 STAT5A STAT5B STAT6 STMN1 SULT2A1 SUMO4 SUPT20H SYK TASOR2 TDG TM4SF19 TRIM28 TRIP10 TSHR TSLP TWIST1 VPS39 WDFY3 ZFPM2 ZNF148 ZNF281 ZNF467 ZNF557 ZNF829 ZNRD2	38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB STAT3 SYT1 TMCO3 TMEM119 TSHB
Entrez ID		6774	7253
HPRD ID		00026	04537
Ensembl ID		ENSG00000168610	ENSG00000165409
Uniprot IDs		P40763	A0A0A0MTJ0 P16473
PDB IDs		5AX3 5U5S 6NJS 6NUQ 6QHD 6TLC	1XUM 2XWT 3G04
Enriched GO Terms of Interacting Partners?
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